A γ-radiation-responsive diselenide-core micelle for on-demand delivery of cannabidiol in the mitigation of acute radiation injury

Abstract With the widespread application of nuclear energy, the associated risks of nuclear accidents and radiation leakage have increased considerably. To address potential acute radiation injuries and reduce the toxicity burden posed by conventional radioprotective agents, the development of novel therapeutic strategies is urgently needed. In this study, we designed a γ-radiation-responsive drug delivery system by encapsulating the radioprotective agent cannabidiol (CBD) into amphiphilic polymer micelles (denoted as mPEG-SeSe-St@CBD) incorporating diselenide bonds as radiation-sensitive units. The resulting micelles exhibited a