Phytochemical Profiling, Antiplatelet Potential, and Cytotoxic Assessment of Thymelaea tartonraira Aerial Part Essential Oil: In Vitro and In Silico Studies

Abstract This study evaluates the antiplatelet potential of Thymelaea tartonraira essential oil, obtained from aerial parts by hydrodistillation. GC–MS analysis identified 43 compounds, with phenethyl alcohol (25.69%), eugenol (12.42%), and carvacrol (6.41%) as major constituents. In vitro platelet aggregation assays showed significant inhibition, with IC50 values of 6.37, 10.92, and 15.32 µL/mL against aggregation induced by ADP, collagen, and arachidonic acid, respectively. Molecular modeling (in silico docking) against P2Y12, cyclooxygenase‐1, and the glycoprotein GPVI revealed strong interactions of eugenol and