Cannabidiol Protects Against 1‐Methyl‐4‐Phenylpyridinium and Manganese‐Induced Neurotoxicity via Nod‐Like Receptor Protein 3 Inflammasome Suppression

Abstract Parkinson’s disease (PD) is a neurodegenerative disorder characterized by dopaminergic neurodegeneration, alpha‐synuclein (α‐Syn) accumulation, and neuroinflammation. The NOD‐Like Receptor (NLR) family pyrin domain containing 3 NLRP3 inflammasome has recently been identified as a central mediator of PD‐associated inflammatory responses. Cannabidiol (CBD), a non‐psychoactive phytocannabinoid, exhibits anti‐inflammatory and neuroprotective properties; however, its effects on NLRP3 inflammasome in PD remain insufficiently understood. This study investigated the neuroprotective effects of CBD‐rich oil against 1‐methyl‐4‐phenylpyridinium (MPP+) and manganese‐induced neurotoxicity in SH‐SY5Y cells. Cells