The association between state cannabis legalization and non-fatal opioid poisonings among adults with employer-sponsored insurance in the United States

Abstract Objective: Although many states have legalized medical and recreational cannabis, its association with non-fatal opioid poisonings remains unclear. This study examines the association between state cannabis legalization policies and non-fatal opioid poisoning diagnoses among enrollees in employer-sponsored health insurance. Methods: The study included 107,480,711 enrollees aged 18–64 with ≥1 year of continuous enrollment (average age 41; 52% females) in the Merative MarketScan Commercial Claims and Encounters Database (2011−2021) in the United States. Utilizing a staggered adoption difference-in-differences regression, this