Abuse potential assessment of novel central nervous system active and psychedelic substances for controlled substances act scheduling recommendations

Abstract Introduction: Abuse potential assessment of drugs with central nervous system activity is a critical component of the development of new medications for regulatory filings for approval worldwide. These new drug applications typically include recommendations for scheduling status as a controlled substance, if scheduling is warranted. This commentary focuses on the approach and current issues related to scheduling in the United States (US) Controlled Substances Act (CSA); however, scheduling more globally generally involves similar approaches and issues. Although scheduling is