Safety considerations for patients using cannabis

Abstract Cannabis is the most used federally illicit substance in the United States, yet there is limited knowledge about its pharmacology; efficacy for various medical conditions; or, more importantly, its safety profile. There is significant interest in exploring the full extent of the pharmacologic effects of cannabinoids. Psychoactive effects of cannabis are well-established, but the other effects of cannabinoids, including their effect on mood symptoms; suicidal ideation; and activity outside of the central nervous system, including actions on the cardiovascular