Porous starch as an effective carrier for sustained release and bioactivity protection of cannabidiol full spectrum oil

Abstract Full-spectrum cannabidiol oil (CFSO) has attracted growing attention across industries for its multiple health benefits, but its poor water solubility and low bioavailability remain unresolved challenges. In this study, porous starch (PS) was used as a wall material to encapsulate CFSO, and the physicochemical properties, water solubility, bioavailability, and antioxidant activity of the encapsulated product were evaluated. Results confirmed the successful preparation of PS-CFSO. Using Box-Behnken design response surface methodology, the maximum encapsulation efficiency (80.69 ± 0.71 %) was