The role of the kynurenine pathway in conditioned place aversion induced by synthetic cannabinoid CP-55940

Abstract Background: The therapeutic potential of cannabinoids is increasingly recognized; however, their use is often associated with adverse effects, such as conditioned place aversion (CPA). The molecular mechanisms underlying CPA remain poorly understood, particularly the role of the kynurenine pathway (KP) and its interaction with cannabinoid receptors. This study aimed to elucidate these mechanisms, focusing on the synthetic. Methods: We employed a mouse conditioned place preference behavioral model to assess CPA following the administration of CP-55940 at a dosage of