Unraveling Cannabidiol’s Dual Modulatory Role in Schizophrenia: Network Pharmacology and In Vivo Validation of Neuroinflammatory and Behavioral Modulation

Abstract Supplementary Information: The online version contains supplementary material available at 10.1007/s12035-025-05608-8. Article type: Research Article Keywords: Cannabidiol, Schizophrenia therapy, Network pharmacology, Neuroinflammation, 5HT1AR-MAPK signaling pathway Authors: Ying Wei, Xiang Liu, Shijun Lin, Zhiwei Jia, Lin Liu, Baiqiang Wang, Linchuan Liao, Xue Mei Affiliations: https://ror.org/05k3sdc46grid.449525.b0000 0004 1798 4472College of Pharmacy, North Sichuan Medical College, Nanchong, China; https://ror.org/05k3sdc46grid.449525.b0000 0004 1798 4472Biotechnology Innovation Drug Application and Transformation Key Laboratory of Sichuan Province, North Sichuan Medical College, Nanchong, 637000 Sichuan Province China; https://ror.org/01673gn35grid.413387.a0000