Acute Effects of Oral Cannabinoids on Sleep and High‐Density EEG in Insomnia: A Pilot Randomised Controlled Trial

Abstract Cannabinoids, particularly Δ9‐tetrahydrocannabinol (THC) and cannabidiol (CBD), have gained popularity as alternative sleep aids; however, their effects on sleep architecture and next‐day function remain poorly understood. Here, in a pilot trial, we examined the effects of a single oral dose containing 10 mg THC and 200 mg CBD (THC/CBD) on objective sleep outcomes and next‐day alertness using 256‐channel high‐density EEG in 20 patients with DSM‐5 diagnosed insomnia disorder (16 female; mean (SD) age, 46.1 (8.6) years). We showed that