Association of cannabis use disorder with postoperative complications following panniculectomy: a multicenter propensity-matched analysis

Abstract Background: As cannabis use continues to rise globally, its impact on surgical outcomes remains poorly characterized. Cannabinoids modulate immune, nociceptive, and vascular pathways, with implications for postoperative healing. This study aimed to evaluate whether cannabis use disorder (CUD) is independently associated with increased complications following infraumbilical panniculectomy. Methods: A retrospective cohort study was conducted using the TriNetX Research Network, a globally federated database of de-identified electronic health records from over 100 healthcare organizations. Adult patients (≥ 18 years old)