Antiseizure Effects of Cannabidiol in Combination With Cannabigerol in the Maximal Electroshock Seizure Model

Abstract Current antiseizure therapy for epilepsy is only effective in about 70% of the patient population. Previous studies had shown that the addition of small amounts of tetrahydrocannabinol (THC) made cannabidiol (CBD) much more potent in the maximal electroshock seizure (MES) model. The psychotoxic effects of THC make it unsuitable as an antiseizure therapy. The current study investigated the effects of combining CBD with the non‐psychotoxic cannabinoid cannabigerol (CBG) in the MES model in mice. Mice were administered (i.p.) CBD