Cannabidiol mitigates secondary genital injury after thoracic trauma by regulating systemic inflammation and hormone receptor signaling

Abstract Blunt thoracic trauma–induced pulmonary contusion is a major cause of acute lung injury and triggers a systemic inflammatory response characterized by cytokine release, oxidative stress, and apoptosis. These systemic effects may disrupt vascular homeostasis and contribute to secondary injury in distant organs, particularly within the female reproductive system, which is dependent on vascular and hormonal balance. This study evaluated the effects of cannabidiol (CBD), a non-psychotropic phytocannabinoid with anti-inflammatory, antioxidant, and anti-apoptotic properties, on secondary reproductive organ injury following