Oral Cannabidiol in the Treatment of Myofascial Pain Disorder of the Temporomandibular Region: A Placebo-Controlled Randomized Clinical Trial

Abstract Introduction: The efficacy of oral cannabidiol (CBD) for the management of myofascial pain disorder (MPD) of the temporomandibular region remains understudied. Therefore, the purpose of this study was to determine whether cannabinoids provide pain relief and improve jaw function in patients with MPD of the temporomandibular region. Methods: This is a single-center, prospective, double-blind, randomized, and placebo-controlled clinical trial. Subjects with pain (≥30 on Visual Analog Scale [VAS]) were screened for MPD as defined by the Diagnostic Criteria for