Cannabidiol Enhances Atezolizumab Efficacy by Upregulating PD-L1 Expression via the cGAS–STING Pathway in Triple-Negative Breast Cancer Cells

Abstract The anti–PD-L1 atezolizumab has limited efficacy in TNBC. The authors show that combining atezolizumab with cannabidiol enhances PD-L1 expression on PD-L1+ TNBC cells, improving T cell–mediated TNBC killing in vitro and TNBC control in syngeneic models. Authors: Bu Gyeom Kim ⚬, Bo Ram Kim ⚬, Dae Yeong Kim ⚬, Woo Young Kim ⚬, Sanghee Kang ⚬, Sun Il Lee ⚬, Sang Cheul Oh ⚬ Affiliations: Department of Oncology, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Republic