Effect of Inhaled Cannabis for Pain in Adults With Sickle Cell Disease

Abstract Question: Is inhaled cannabis with an approximately 1:1 ratio of Δ-9-tetrahydrocannabinol to cannabidiol a safe and effective adjunct to opioids in adults with sickle cell disease–related pain? Findings: This randomized clinical trial including 23 participants found that inhaled cannabis was safe. Inhaled cannabis was more effective than inhaled placebo in interference in mood, but there was no statistically significant difference in pain rating between cannabis and placebo. Meaning: These findings suggest that cannabis should be investigated further in larger