Sex differences in normative modeling of cortical thickness in cannabis use disorder

Abstract Cannabis use disorder (CUD) is associated with sexually dimorphic behavioral and neurobiological effects, but sex differences in a broader sampling of brain structures in CUD assessed relative to normative reference values have not been examined. Here, we assessed sex differences in brain regions measured via 3 T MRI in 72 adults (50 males, 22 females) with CUD. T1-weighted images, segmented via FreeSurfer, were used to derive Normative Morphometry Imaging Statistics z-scores (accounting for age, sex, intracranial volume, and image