Cannabidiol potentiates hyperpolarization-activated cyclic nucleotide–gated (HCN4) channels

Abstract HCN4 channels play an important role in cardiac action potential initiation in the sinoatrial node. In this study, Page and Ruben find that cannabidiol potentiates HCN4 channels independently of other activators (cAMP) and agonists (PIP2) via binding to a lipid-binding pocket at the C-terminus of the voltage sensor. Authors: Dana A. Page ⚬, Peter C. Ruben ⚬ Affiliations: Department of Biomedical Physiology and Kinesiology, https://ror.org/0213rcc28Simon Fraser University, Burnaby, Canada License: © 2024 Page and Ruben CC BY-NC-SA 4.0 This