Aqueous cannabidiol β-cyclodextrin complexed polymeric micelle nasal spray to attenuate in vitro and ex vivo SARS-CoV-2-induced cytokine storms

Keywords: Cannabidiol, β-Cyclodextrin, Polymeric micelles, Nasal spray solution, SARS-CoV-2, Pro-inflammatory cytokine Authors: Narumon Changsan, Somchai Sawatdee, Roongnapa Suedee, Charisopon Chunhachaichana, Teerapol Srichana Affiliations: College of Pharmacy, Rangsit University, Pathumtani 12000, Thailand; Drug and Cosmetics Excellence Center and School of Pharmacy, Walailak University, Thasala, Nakhon Si Thammarat 80161, Thailand; Molecular Recognition Materials Research Unit, Nanotec-PSU Center of Excellence on Drug Delivery System Department of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Prince of Songkla University Hat Yai, Songkhla 90112, Thailand; Drug Delivery