Pain response to cannabidiol in opioid-induced hyperalgesia, acute nociceptive pain, and allodynia using a model mimicking acute pain in healthy adults in a randomized trial (CANAB II)

Abstract A single oral dose of 1600-mg cannabidiol failed to reduce opioid-induced hyperalgesia by remifentanil in healthy adult volunteers in a fasted state, in a model of acute pain. Article type: Research Article Keywords: Cannabidiol, Acute pain, Hyperalgesia, Allodynia, Opioid-induced hyperalgesia, Remifentanil Authors: Markus Dieterle, Laura Zurbriggen, Eckhard Mauermann, Katja Mercer-Chalmers-Bender ⚬, Priska Frei ⚬, Wilhelm Ruppen, Tobias Schneider ⚬ Affiliations: Clinic for Anaesthesia, Intermediate Care, Prehospital Emergency Medicine and Pain Therapy, University Hospital of Basel, Basel, Switzerland; Institute of