Endocannabinoid-dependent formation of columnar axonal projection in the mouse cerebral cortex

Abstract One of the most important morphological properties in the cerebral cortex is the columnar structure, where axonal projections occur precisely within individual vertical columns. However, how such precise axonal projections arise during development is not well known. Previous studies indicate that columnar topographical axonal projections are achieved by selective addition of axons within individual columns without identifying the molecule involved in this process. We show that the endocannabinoid is crucial for shaping columnar axonal projections of layer 4 neurons