The effects of cannabis abstinence on cognition and resting state network activity in people with multiple sclerosis: A preliminary study

Abstract Cannabis use may exacerbate cognitive impairment in MS patients, whereas abstinence can result in improved brain activation and cognitive performance. Cannabis-related cognitive impairment in MS may disrupt the default mode network. Abstinence from cannabis was linked to better cognitive outcomes but did not show a significant impact on depression, anxiety, or fatigue. Article type: Research Article Keywords: Multiple sclerosis, Resting state, Cognitive impairment, Cannabis Authors: Cecilia Meza, Cristiana Stefan, W. Richard Staines, Anthony Feinstein Affiliations: Sunnybrook Research Institute, Division