The cannabinoid dehydroxylcannabidiol suppresses neuropathic pain by upregulating a spinal glycine receptor-mediated compensation mechanism

Abstract Neuropathic pain (NP) is well-known to be complicated and challenging to manage. Organisms have been shown to initiate various intrinsic compensatory strategies to alleviate NP, which could be utilized to aid the development of therapeutic treatments. However, these mechanisms that alleviate NP have not been fully elucidated. Here we show that spinal glycine receptor α1 (GlyRα1) is a key element of an intrinsic compensatory mechanism to alleviate NP. This spinal GlyRα1-mediated compensatory mechanism is manifested in many ways, including