High and Mighty? Cannabinoids and the microbiome in pain

Abstract In this review, we will focus on the potential role of the endogenous cannabinoids in modulating microbiota-driven changes in peripheral and central pain processing. We also focus on the overlap in mechanisms whereby commensal gut microbiota and endocannabinoid ligands can regulate inflammation and further aim to exploit our understanding of their role in microbiota-gut-brain axis communication in pain processing. Article type: Research Article Keywords: Endocannabinoids, Microbiota, Inflammation, Pain, Gut Authors: Kieran Rea, Siobhain M. O’ Mahony, John F. Cryan