TRP channels in hepatocellular carcinoma: integrative Mendelian randomization and multi-omics analyses highlight MCOLN3/TRPV4 as candidate dual-effect biomarkers

Abstract Background: The causal relationship between Transient receptor potential (TRP) and hepatocellular carcinoma (HCC) remains unclear. Our study aimed to identify potential drug targets for HCC within the TRP family using Mendelian randomization (MR). Methods: The gene expression quantitative trait loci (eQTL) data for TRP was sourced from eQTLGen Consortium. Summary statistics for HCC came from European (nCase = 379, nControl = 475,259) and East Asian population (nCase = 2122, nControl = 159,201). We undertook main MR analysis in the