Range of SHH signaling in adrenal gland is limited by membrane contact to cells with primary cilia

Abstract Mateska et al. describe a mechanism restricting the range of SHH pathway activation in adrenal gland to cells with ARL13B-positive primary cilia that are in physical contact with SHH-producing cells. Cancerous adrenocortical cells evade this restriction by ectopically activating SHH targets in response to TGF-β. Authors: Ivona Mateska ⚬, Kareena Nanda, Natalie A. Dye ⚬, Vasileia Ismini Alexaki ⚬, Suzanne Eaton Affiliations: Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany; Biotechnologisches Zentrum, Technische Universität Dresden, Dresden,