Lung Health and Breath Biomarkers: Acute Effects of Combusted and Vaporized Cannabis Inhalation Compared to Tobacco Cigarette Combustion in the Human Laboratory

Exclusion criteria

• 1. Physiologic drug dependence on opioids, benzodiazepines, barbiturates, and/or alcohol that would require medical management, 2. Clinically significant acute medical problem (e.g., infection) or chronic medical problem requiring daily medication or ongoing medical care (e.g., hypertension, cardiovascular disease, diabetes, respiratory disorders \[e.g., asthma, COPD\]), 3. Existing or significant lung health problems that could interfere with the study, 4. Current or history of major psychiatric disorder that would limit the participant's ability to participate in the study (e.g., bipolar disorder), 5. Exclusive use of tobacco or cannabis through vapes and Electronic Nicotine Delivery Systems (ENDS) products, 6. Currently using daily prescription medications to manage medical conditions or any drug that could interfere with the study (as determined by the study physician), 7. Clinically significant abnormal ECG (as determined by study physician/cardiologist), 8. Clinically significant abnormal laboratory findings (e.g., liver function tests greater than 3x the upper limits of normal range), 9. History of seizure disorder, 10. Clinically significant history of head injuries requiring medical management or long-lasting sequelae.