Dronabinol
Oral dronabinol capsules (40 mg)
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This study investigates sex differences in reward processing following acute THC administration in adults with cannabis use disorder (CUD). Using multimodal neuroimaging (MRS and fMRI), the study will assess glutamate levels in the nucleus accumbens and striatal BOLD response to monetary reward anticipation. Participants will complete two counterbalanced dosing sessions (oral THC 40 mg vs. placebo).
Locally preserved from ClinicalTrials.govOpen ClinicalTrials.govlast source update 2026-09-08
What this record can show
This locally preserved record separates the registered protocol from source-reported registry results. Neither is a treatment recommendation.
Registry facts
Linked local records
Local links use governed condition terms or exact source-reported intervention names. They are navigation candidates, not efficacy claims.
Interventions
Oral dronabinol capsules (40 mg)
MarinolMatched placebo capsules
Eligibility
primary outcomes
Time frame: 2 hours post-dose
Concentrations of nucleus accumbens glutamate measured via proton magnetic resonance spectroscopy
Time frame: 3 hours post-dose
Blood oxygen-level-dependent (BOLD) signaling in the striatum (caudate, putamen, nucleus accumbens) measured using functional magnetic resonance imaging (fMRI) during a monetary reward task
secondary outcomes
Time frame: 0-7 hours
Visual Analog Scale rating of subjective drug liking included in the Drug Effects Questionnaire. Score ranges from 0 (not at all) to 100 (extremely) using a 100mm line anchored with none/extreme designation.
Time frame: 0-7 hours
Visual Analog Scale rating of subjective desire for more of the same drug included in the Drug Effects Questionnaire. Score ranges from 0 (not at all) to 100 (extremely) using a 100mm line anchored with none/extreme designation.
Time frame: 0-7 hours
Visual Analog Scale rating of subjective "high" included in the Drug Effects Questionnaire. Score ranges from 0 (not at all) to 100 (extremely) using a 100mm line anchored with none/extreme designation.
Time frame: 2 hours post-dose
Concentrations of nucleus accumbens GABA measured via proton magnetic resonance spectroscopy
Publications
No exact PMID-linked public article is currently readable locally.