OBSERVATIONALRECRUITINGNCT07167225

Carcinogen and Toxicant Exposure Among Young Adults Who Co-Use E-cigarettes and Cannabis (Co-Tox Study)

This study evaluates the amount of nicotine, cannabis, and toxicants linked to the use of nicotine e-cigarette and/or cannabis products in the blood and urine of young adult users as well as the cannabis and nicotine use behaviors of consumers.

Locally preserved from ClinicalTrials.govOpen ClinicalTrials.govlast source update 2026-08-26

What this record can show

Protocol only - no registry results posted

This locally preserved record separates the registered protocol from source-reported registry results. Neither is a treatment recommendation.

Registry facts

Study at a glance

Phase: Not reported
Enrollment: 150 (ESTIMATED)
Start date: 2025-04-03
Sponsor: Roswell Park Cancer Institute
Design: Not reported
Locations: 1
Results record: Not present in registry snapshot

PRIMARY OBJECTIVE: I. To evaluate differences in self-reported nicotine and cannabis use behaviors and biomarkers of exposure to toxicants and carcinogens by product use status, to generate effect sizes required to calculate sample sizes needed for a larger study.

Linked local records

Related local records

Local links use governed condition terms or exact source-reported intervention names. They are navigation candidates, not efficacy claims.

Conditions

No published condition report matched.

Cannabinoids and active compounds

No governed compound link was found.

Medicines

No exact medicine-name link was found.

Interventions

What was registered

OTHER

Effectiveness of different recruitment approaches

Subjects will asked which type of recruitment material they've seen when completing the screening survey

OTHER

Choice of study completion locations

subjects will choose location when coordinator calls to schedule appointment

OTHER

Cannabis Engagement Assessment

Self reported measure of current cannabis use that contains 30 questions assessing quantity, frequency of use and method of consumption in the past 30 days.

OTHER

E-cigarette dependence Scale

A 22-item questionnaire measuring e-cigarette dependence. Higher scores indicate greater dependence.

OTHER

Nicotine dependence Scale

Self reported measure of current nicotine use that contains 27 questions assessing quantity, frequency of use in past 6 months

OTHER

Co use practices QUestionnaire

Self reported measure of nicotine and cannabis use that contains 25 questions assessing quantity, frequency and practices of use in past 30 days

Eligibility

Population and criteria

Sex: ALL
Minimum age: 18 Years
Maximum age: 25 Years
Healthy volunteers: Accepted

Study population

Young adults (18-25 year old) currently using cannabis products and/or electronic cigarettes containing nicotine.

Inclusion criteria

Young adult (18-25 years old).
Ability to read and write in English.
Participants must fall into one of the following groups (based on self-report):
Predominant e-cigarette consumer: defined as using nicotine-containing e-cigarettes daily for the past six months but not having used other nicotine containing products more than weekly or cannabis products for the past month.
Predominant cannabis consumer: defined as using cannabis at least 3x/week for the past six months in any form, including smoking, vaping, and oral use, with no more than weekly use of any nicotine or tobacco products.
E-cigarette-cannabis co-consumers: defined as daily use of nicotine e-cigarettes and use of cannabis at least 3x/week, including smoking, vaping, and oral use, for at least the past six months, with no use of other nicotine containing products more than weekly
Predominant cigarette consumers: defined as using cigarettes at least daily for the past six months, but not have used other nicotine-containing products more than weekly or cannabis products for the past month
Predominant cigarette-cannabis co-consumers: defined as those reporting daily cigarette use and use of cannabis at least 3x/week (including smoking or vaping) for at least the past six months, with no more than weekly use of other nicotine-containing products
No self-reported diagnosis of kidney disease (current, or within the past year prior to the study visit).
Participants must understand the voluntary nature of this study and sign a written informed consent form before proceeding with study activities.

Exclusion criteria

Individuals under the age of 18 or over the age of 25.
Currently pregnant or breastfeeding (female participants).
Unwilling or unable to follow protocol requirements

primary outcomes

primary measures

Differences in biomarker levels across groups

Time frame: 1 study session lasting 1 hour

Will compare the mean biomarker levels between groups using a one-way ANOVA model, with Bonferroni-adjusted pairwise comparisons, as appropriate.

secondary outcomes