Cannabis plant (THC 20mg)
Cannabis flower - very High THC (\>10%) / Low CBD (\<1%)
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The purpose of this study is to understand the direct effects of cannabis on male reproductive functions. The investigators plan to conduct a double-blind, placebo-controlled clinical trial to examine both the chronic and acute effects of cannabis use on male reproductive functions. Specifically, the investigators will examine the dose-dependent effects of acute cannabis use on male reproductive parameters, including sperm counts, motility, morphology, and testosterone levels, as well as sperm epimutations. Participants \[cannabis users will be randomly assigned to 1) non-vaping, 2) placebo (vaping without cannabis), and 2 doses of cannabis, 3) 20 and 4) 40mg of THC in cannabis flower obtained from the NIDA drug supply\], and 5) non-cannabis users (naïve control, no cannabis or placebo exposure). Participants will provide surveys (cannabis use and sexual functioning and satisfaction etc.), peripheral blood, and semen.
Locally preserved from ClinicalTrials.govOpen ClinicalTrials.govlast source update 2026-08-19
What this record can show
This locally preserved record separates the registered protocol from source-reported registry results. Neither is a treatment recommendation.
Registry facts
The Volcano Vaporizer will be used to expose cannabis or placebo plants.
Linked local records
Local links use governed condition terms or exact source-reported intervention names. They are navigation candidates, not efficacy claims.
Interventions
Cannabis flower - very High THC (\>10%) / Low CBD (\<1%)
marijuanaTHC (0%) / CBD (0%) - Placebo marijuana
Cannabis flower - very High THC (\>10%) / Low CBD (\<1%)
marijuanaEligibility
primary outcomes
Time frame: 30 minutes
Sperm counts and motility, as well as DNA fragmentation, will be examined after vaping or no vaping.
Time frame: 30 minutes
Differentially methylated regions in sperm will be analyzed to examine the effects of cannabis exposure.
Time frame: 4 hours
Plasma testosterone and THC/THC metabolites will be analyzed to examine the effects of cannabis exposure.
secondary outcomes
Time frame: 4 hours
After the vaping session and semen collection, participants will complete the Acute Stress Test. Plsama cortisol will be analyzed before and after the Acute Stress Test. During sobering (\~4 hours), snacks (e.g., fruit snacks, granola bars, chips, chocolate, soda, juice, and water) will be available for participants. Investigators will monitor participants via the window in the adjacent room to monitor and record the snacks/beverages participants choose to consume.
Publications
No exact PMID-linked public article is currently readable locally.