Dronabinol Pill
Dronabinol 20 mg
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Alcohol and cannabis are often used together such that their effects overlap, but little is known about the neural mechanisms that underlie simultaneous use. High doses of THC have not been well-studied in the laboratory, and it is unclear how high doses of THC may impact alcohol consumption patterns. The proposed study will explore the effects of oral THC (20mg dronabinol) vs. placebo on neural reward, alcohol self-administration and naturalistic co-use patterns.
Locally preserved from ClinicalTrials.govOpen ClinicalTrials.govlast source update 2024-08-19
What this record can show
This locally preserved record separates the registered protocol from source-reported registry results. Neither is a treatment recommendation.
Registry facts
Participants will undergo a screening assessment, baseline session and two laboratory visits. The laboratory visits will involve an MRI scan and the opportunity to consume alcohol in our BAR lab. Prior to the MRI, participants will consume, a placebo (0mg) or high (20mg) dose of oral THC (dronabinol). Visits will be separated by 7 to 14 days. Dronabinol is an FDA-approved product that will be dispensed by our on-campus pharmacy
Linked local records
Local links use governed condition terms or exact source-reported intervention names. They are navigation candidates, not efficacy claims.
Interventions
Dronabinol 20 mg
placebo
Eligibility
primary outcomes
Time frame: 1 hour after administration of a single dose of study medication at 7 days, 14 days.
Alcohol cue reactivity task BOLD signal to alcohol cues, relative to neutral beverage cues
Time frame: 1 hour after administration of a single dose of study medication at 7 days, 14 days.
Cannabis cue reactivity task BOLD signal to cannabis cues, relative to neutral cues
Time frame: 3-4 hours after administration of a single dose of study medication at 7 days, 14 days.
Number of drinks self-administered
Time frame: one report per day for the 14 days after the final laboratory visit on day 14.
\# of drinks consumed per day
Time frame: One report per day for the 14 days after the final laboratory visit on day 14
Amount of cannabis consumed per day
Time frame: One report per day for the 14 days after the final laboratory visit on day 14.
Number of days in which cannabis and alcohol were both used
Publications
No exact PMID-linked public article is currently readable locally.