Pharmacokinetics and Pharmacodynamics of Oral and Vaporized Delta-9-Tetrahydrocannabinol (THC) in Older Adults

Exclusion criteria

• 1. Meeting DSM-5 criteria for psychiatric/substance use disorders (SUD) other than tobacco use disorder, within the last year 2. Current use of cannabinoid products, as evidenced by a urine drug screen 3. Having a history of treatment for cannabis use disorder 4. History of intent or current intent of abstaining from cannabis use 5. Clinically significant medical disorders (e.g. liver/kidney dysfunction, immunosuppressing conditions, history or presence of epilepsy, seizures, head trauma with loss of consciousness) 6. Medical conditions that increase the risk of respiratory problems (e.g. COPD, asthma, recuring bronchitis, reactive airway disorder)\* (does not apply to the Oral THC Sub-Study) 7. History of environmental sensitivities (e.g. bronchospastic allergies, multiple chemical sensitivities) or other airway sensitivities that require the use of an epi pen\*(does not apply to the Oral THC Sub-Study) 8. Neurological conditions that may change the response to nociceptive stimuli (e.g., stroke, neuropathy), or that lead to loss of balance, evidenced by a neuro-sensory exam 9. Contraindications for exposure to nociceptive stimuli, such as untreated hypertension 10. Current regular use of drugs known to affect pain, or that are prominent inducers or inhibitors of CYP2C9, CYP3A4, or UGTA19 (e.g., carbamazepine, valproate, fluvoxamine, and paroxetine) 11. Major neurocognitive disorders precluding participation, evidenced by a clinical exam 12. Abnormal EKG, arrythmia, vasospastic disease, chronic heart failure, or presence of a pacemaker 13. Elevation of liver enzymes (ALT, AST) 2x the normal limit or higher 14. Personal or family history of primary psychotic disorders, or mood disorders with psychotic features 15. Current suicidal ideation 16. Allergy or serious adverse reactions to sesame oil, THC, or cannabis 17. Having received any drug as part of a research study within 30 days prior to receiving the study medication in the current study.