Marijuana
Double-blind administration of marijuana
CannabisLoading study record…
The primary goals of this study are to examine 1) marijuana modulation of oxycodone self-administration and 2) oxycodone modulation of marijuana self-administration, under controlled conditions and across a range of doses for each drug.
Locally preserved from ClinicalTrials.govOpen ClinicalTrials.govlast source update 2026-04-15
What this record can show
Results are reported by the registry submitter and preserved exactly. They are not independent verification or a treatment recommendation.
Registry facts
Linked local records
Local links use governed condition terms or exact source-reported intervention names. They are navigation candidates, not efficacy claims.
Interventions
Double-blind administration of marijuana
CannabisDouble-blind administration of an opioid agonist
Source-reported results
Results are reported by the registry submitter and preserved exactly. They are not independent verification or a treatment recommendation.
The number of units of drug (out of a total of 7) earned in each experimental condition. Participants work for some, none, or all of the available drug dose. For each dose condition, the number of drug units completed for drug was pulled from the raw data and averaged to yield one mean (SEM).
| Group | N | Value | Spread / interval |
|---|---|---|---|
| Oxycodone 0mg / Self-Admin Dose: THC 0mg | 6 | 0.00 | 0.00 |
| Oxycodone 0mg / Self-Admin Dose: THC 10mg | 6 | 3.83 | 0.95 |
| Oxycodone 0mg / Self-Admin Dose: THC 30mg | 6 | 3.67 | 0.21 |
| Oxycodone 45mg / Self-Admin Dose: THC 0mg | 6 | 0.00 | 0.00 |
| Oxycodone 45mg / Self-Admin Dose: THC 10mg | 6 | 3.17 | 0.70 |
| Oxycodone 45mg / Self-Admin Dose: THC 30mg | 6 | 3.00 | 0.63 |
| THC 0mg / Self-Admin Dose: Oxycodone 0mg | 6 | 0.00 | 0.00 |
| THC 0mg / Self-Admin Dose: Oxycodone 15mg | 6 | 4.33 | 0.71 |
| THC 0mg / Self-Admin Dose: Oxycodone 45mg | 6 | 4.00 | 0.37 |
| THC 30mg / Self-Admin Dose: Oxycodone 0mg | 6 | 0.33 | 0.33 |
Eligibility
primary outcomes
Time frame: Through a progressive-ratio self-administration model given once per treatment condition throughout each 6 hour session
The number of units of drug (out of a total of 7) earned in each experimental condition. Participants work for some, none, or all of the available drug dose. For each dose condition, the number of drug units completed for drug was pulled from the raw data and averaged to yield one mean (SEM).
secondary outcomes
Time frame: This outcome was recorded prior to and in regular intervals after drug administration for the duration of each session (approximately 6 hours).
End-tidal Carbon Dioxide (EtCO2): For each dose condition, the participants' peak value was pulled from the raw data and averaged to yield one mean (SEM). Higher scores indicate greater impairment.
Time frame: This outcome was recorded prior to and in regular intervals after drug administration for the duration of each session (approximately 6 hours).
Respiration rate (number of breaths per minute): For each dose condition, the participants' trough value was pulled from the raw data and averaged to yield one mean (SEM). Lower scores indicate greater impairment.
Publications
No exact PMID-linked public article is currently readable locally.
| THC 30mg / Self-Admin Dose: Oxycodone 15mg | 6 | 2.33 | 0.76 |
| THC 30mg / Self-Admin Dose: Oxycodone 45mg | 6 | 3.33 | 0.88 |
End-tidal Carbon Dioxide (EtCO2): For each dose condition, the participants' peak value was pulled from the raw data and averaged to yield one mean (SEM). Higher scores indicate greater impairment.
Population: Per Protocol population, defined as participants completing the 12 experimental drug conditions.
| Group | N | Value | Spread / interval |
|---|---|---|---|
| Oxycodone 0mg / Self-Admin Dose: THC 0mg | 6 | 38.50 | 0.85 |
| Oxycodone 0mg / Self-Admin Dose: THC 10mg | 6 | 39.17 | 1.14 |
| Oxycodone 0mg / Self-Admin Dose: THC 30mg | 6 | 40.17 | 1.08 |
| Oxycodone 45mg / Self-Admin Dose: THC 0mg | 6 | 43.50 | 1.18 |
| Oxycodone 45mg / Self-Admin Dose: THC 10mg | 6 | 43.17 | 1.11 |
| Oxycodone 45mg / Self-Admin Dose: THC 30mg | 6 | 45.50 | 0.85 |
| THC 0mg / Self-Admin Dose: Oxycodone 0mg | 6 | 38.67 | 1.12 |
| THC 0mg / Self-Admin Dose: Oxycodone 15mg | 6 | 42.50 | 1.41 |
| THC 0mg / Self-Admin Dose: Oxycodone 45mg | 6 | 42.67 | 1.93 |
| THC 30mg / Self-Admin Dose: Oxycodone 0mg | 6 | 40.83 | 1.22 |
| THC 30mg / Self-Admin Dose: Oxycodone 15mg | 6 | 41.50 | 1.06 |
| THC 30mg / Self-Admin Dose: Oxycodone 45mg | 6 | 42.00 | 1.44 |
Respiration rate (number of breaths per minute): For each dose condition, the participants' trough value was pulled from the raw data and averaged to yield one mean (SEM). Lower scores indicate greater impairment.
| Group | N | Value | Spread / interval |
|---|---|---|---|
| Oxycodone 0mg / Self-Admin Dose: THC 0mg | 6 | 11.83 | 1.14 |
| Oxycodone 0mg / Self-Admin Dose: THC 10mg | 6 | 12.17 | 1.01 |
| Oxycodone 0mg / Self-Admin Dose: THC 30mg | 6 | 12.33 | 0.80 |
| Oxycodone 45mg / Self-Admin Dose: THC 0mg | 6 | 10.33 | 0.33 |
| Oxycodone 45mg / Self-Admin Dose: THC 10mg | 6 | 10.67 | 0.42 |
| Oxycodone 45mg / Self-Admin Dose: THC 30mg | 6 | 10.83 | 0.83 |
| THC 0mg / Self-Admin Dose: Oxycodone 0mg | 6 | 12.83 | 1.70 |
| THC 0mg / Self-Admin Dose: Oxycodone 15mg | 6 | 11.00 | 0.52 |
| THC 0mg / Self-Admin Dose: Oxycodone 45mg | 6 | 10.33 | 0.88 |
| THC 30mg / Self-Admin Dose: Oxycodone 0mg | 6 | 12.00 | 0.63 |
| THC 30mg / Self-Admin Dose: Oxycodone 15mg | 6 | 11.67 | 0.76 |
| THC 30mg / Self-Admin Dose: Oxycodone 45mg | 6 | 11.50 | 0.96 |
| Milestone | Double-blind Marijuana/Placebo & Opioid/Placebo Administration |
|---|---|
| STARTED | 8 |
| Oxycodone 0mg / Self-Admin Dose: THC 0mg | 7 |
| Oxycodone 0mg / Self-Admin Dose: THC 10mg | 6 |
| Oxycodone 0mg / Self-Admin Dose: THC 30mg | 7 |
| Oxycodone 45mg / Self-Admin Dose: THC 0mg | 7 |
| Oxycodone 45mg / Self-Admin Dose: THC 10mg | 6 |
| Oxycodone 45mg / Self-Admin Dose: THC 30mg | 6 |
| THC 0mg / Self-Admin Dose: Oxycodone 0mg | 6 |
| THC 0mg / Self-Admin Dose: Oxycodone 15mg | 6 |
| THC 0mg / Self-Admin Dose: Oxycodone 45mg | 6 |
| THC 30mg / Self-Admin Dose: Oxycodone 0mg | 6 |
| THC 30mg / Self-Admin Dose: Oxycodone 15mg | 6 |
| THC 30mg / Self-Admin Dose: Oxycodone 45mg | 6 |
| COMPLETED | 6 |
| NOT COMPLETED | 2 |
| Event | System | Groups: affected / at risk |
|---|---|---|
| Stubbed toe | Injury, poisoning and procedural complications | Pre-Intervention/Days Off: 1 / 8 · Oxycodone 0mg / Self-Admin Dose: THC 0mg: 0 / 7 · Oxycodone 0mg / Self-Admin Dose: THC 10mg: 0 / 6 · Oxycodone 0mg / Self-Admin Dose: THC 30mg: 0 / 7 · Oxycodone 45mg / Self-Admin Dose: THC 0mg: 0 / 7 · Oxycodone 45mg / Self-Admin Dose: THC 10mg: 0 / 6 · Oxycodone 45mg / Self-Admin Dose: THC 30mg: 0 / 6 · THC 0mg / Self-Admin Dose: Oxycodone 0mg: 0 / 6 · THC 0mg / Self-Admin Dose: Oxycodone 15mg: 0 / 6 · THC 0mg / Self-Admin Dose: Oxycodone 45mg: 0 / 6 · THC 30mg / Self-Admin Dose: Oxycodone 0mg: 0 / 6 · THC 30mg / Self-Admin Dose: Oxycodone 15mg: 0 / 6 · THC 30mg / Self-Admin Dose: Oxycodone 45mg: 0 / 6 · Qualification Condition: THC 20mg / Oxycodone 0mg: 0 / 7 · Qualification Condition: THC 0mg / Oxycodone 30mg: 0 / 8 · Sample Condition: THC 0mg: 0 / 7 · Sample Condition: THC 10mg: 0 / 6 · Sample Condition: THC 30mg: 0 / 7 · Sample Condition: Oxycodone 0mg: 0 / 6 · Sample Condition: Oxycodone 15mg: 0 / 6 · Sample Condition: Oxycodone 45mg: 0 / 6 |
| Right foot pain | Musculoskeletal and connective tissue disorders | Pre-Intervention/Days Off: 1 / 8 · Oxycodone 0mg / Self-Admin Dose: THC 0mg: 0 / 7 · Oxycodone 0mg / Self-Admin Dose: THC 10mg: 0 / 6 · Oxycodone 0mg / Self-Admin Dose: THC 30mg: 0 / 7 · Oxycodone 45mg / Self-Admin Dose: THC 0mg: 0 / 7 · Oxycodone 45mg / Self-Admin Dose: THC 10mg: 0 / 6 · Oxycodone 45mg / Self-Admin Dose: THC 30mg: 0 / 6 · THC 0mg / Self-Admin Dose: Oxycodone 0mg: 0 / 6 · THC 0mg / Self-Admin Dose: Oxycodone 15mg: 0 / 6 · THC 0mg / Self-Admin Dose: Oxycodone 45mg: 0 / 6 · THC 30mg / Self-Admin Dose: Oxycodone 0mg: 0 / 6 · THC 30mg / Self-Admin Dose: Oxycodone 15mg: 0 / 6 · THC 30mg / Self-Admin Dose: Oxycodone 45mg: 0 / 6 · Qualification Condition: THC 20mg / Oxycodone 0mg: 0 / 7 · Qualification Condition: THC 0mg / Oxycodone 30mg: 0 / 8 · Sample Condition: THC 0mg: 0 / 7 · Sample Condition: THC 10mg: 0 / 6 · Sample Condition: THC 30mg: 0 / 7 · Sample Condition: Oxycodone 0mg: 0 / 6 · Sample Condition: Oxycodone 15mg: 0 / 6 · Sample Condition: Oxycodone 45mg: 0 / 6 |
| Itchiness | Skin and subcutaneous tissue disorders | Pre-Intervention/Days Off: 0 / 8 · Oxycodone 0mg / Self-Admin Dose: THC 0mg: 0 / 7 · Oxycodone 0mg / Self-Admin Dose: THC 10mg: 0 / 6 · Oxycodone 0mg / Self-Admin Dose: THC 30mg: 0 / 7 · Oxycodone 45mg / Self-Admin Dose: THC 0mg: 0 / 7 · Oxycodone 45mg / Self-Admin Dose: THC 10mg: 1 / 6 · Oxycodone 45mg / Self-Admin Dose: THC 30mg: 1 / 6 · THC 0mg / Self-Admin Dose: Oxycodone 0mg: 0 / 6 · THC 0mg / Self-Admin Dose: Oxycodone 15mg: 0 / 6 · THC 0mg / Self-Admin Dose: Oxycodone 45mg: 0 / 6 · THC 30mg / Self-Admin Dose: Oxycodone 0mg: 0 / 6 · THC 30mg / Self-Admin Dose: Oxycodone 15mg: 0 / 6 · THC 30mg / Self-Admin Dose: Oxycodone 45mg: 0 / 6 · Qualification Condition: THC 20mg / Oxycodone 0mg: 0 / 7 · Qualification Condition: THC 0mg / Oxycodone 30mg: 0 / 8 · Sample Condition: THC 0mg: 0 / 7 · Sample Condition: THC 10mg: 0 / 6 · Sample Condition: THC 30mg: 0 / 7 · Sample Condition: Oxycodone 0mg: 0 / 6 · Sample Condition: Oxycodone 15mg: 0 / 6 · Sample Condition: Oxycodone 45mg: 1 / 6 |
| Stomach ache | Gastrointestinal disorders | Pre-Intervention/Days Off: 0 / 8 · Oxycodone 0mg / Self-Admin Dose: THC 0mg: 0 / 7 · Oxycodone 0mg / Self-Admin Dose: THC 10mg: 0 / 6 · Oxycodone 0mg / Self-Admin Dose: THC 30mg: 0 / 7 · Oxycodone 45mg / Self-Admin Dose: THC 0mg: 0 / 7 · Oxycodone 45mg / Self-Admin Dose: THC 10mg: 0 / 6 · Oxycodone 45mg / Self-Admin Dose: THC 30mg: 0 / 6 · THC 0mg / Self-Admin Dose: Oxycodone 0mg: 0 / 6 · THC 0mg / Self-Admin Dose: Oxycodone 15mg: 0 / 6 · THC 0mg / Self-Admin Dose: Oxycodone 45mg: 0 / 6 · THC 30mg / Self-Admin Dose: Oxycodone 0mg: 0 / 6 · THC 30mg / Self-Admin Dose: Oxycodone 15mg: 0 / 6 · THC 30mg / Self-Admin Dose: Oxycodone 45mg: 1 / 6 · Qualification Condition: THC 20mg / Oxycodone 0mg: 0 / 7 · Qualification Condition: THC 0mg / Oxycodone 30mg: 0 / 8 · Sample Condition: THC 0mg: 0 / 7 · Sample Condition: THC 10mg: 0 / 6 · Sample Condition: THC 30mg: 0 / 7 · Sample Condition: Oxycodone 0mg: 0 / 6 · Sample Condition: Oxycodone 15mg: 0 / 6 · Sample Condition: Oxycodone 45mg: 0 / 6 |
| Jaw/neck soreness | Musculoskeletal and connective tissue disorders | Pre-Intervention/Days Off: 0 / 8 · Oxycodone 0mg / Self-Admin Dose: THC 0mg: 0 / 7 · Oxycodone 0mg / Self-Admin Dose: THC 10mg: 0 / 6 · Oxycodone 0mg / Self-Admin Dose: THC 30mg: 0 / 7 · Oxycodone 45mg / Self-Admin Dose: THC 0mg: 0 / 7 · Oxycodone 45mg / Self-Admin Dose: THC 10mg: 0 / 6 · Oxycodone 45mg / Self-Admin Dose: THC 30mg: 0 / 6 · THC 0mg / Self-Admin Dose: Oxycodone 0mg: 0 / 6 · THC 0mg / Self-Admin Dose: Oxycodone 15mg: 0 / 6 · THC 0mg / Self-Admin Dose: Oxycodone 45mg: 0 / 6 · THC 30mg / Self-Admin Dose: Oxycodone 0mg: 0 / 6 · THC 30mg / Self-Admin Dose: Oxycodone 15mg: 1 / 6 · THC 30mg / Self-Admin Dose: Oxycodone 45mg: 0 / 6 · Qualification Condition: THC 20mg / Oxycodone 0mg: 0 / 7 · Qualification Condition: THC 0mg / Oxycodone 30mg: 0 / 8 · Sample Condition: THC 0mg: 0 / 7 · Sample Condition: THC 10mg: 0 / 6 · Sample Condition: THC 30mg: 0 / 7 · Sample Condition: Oxycodone 0mg: 0 / 6 · Sample Condition: Oxycodone 15mg: 0 / 6 · Sample Condition: Oxycodone 45mg: 0 / 6 |
| Vomitting / Nausea | Gastrointestinal disorders | Pre-Intervention/Days Off: 0 / 8 · Oxycodone 0mg / Self-Admin Dose: THC 0mg: 0 / 7 · Oxycodone 0mg / Self-Admin Dose: THC 10mg: 0 / 6 · Oxycodone 0mg / Self-Admin Dose: THC 30mg: 0 / 7 · Oxycodone 45mg / Self-Admin Dose: THC 0mg: 0 / 7 · Oxycodone 45mg / Self-Admin Dose: THC 10mg: 0 / 6 · Oxycodone 45mg / Self-Admin Dose: THC 30mg: 0 / 6 · THC 0mg / Self-Admin Dose: Oxycodone 0mg: 0 / 6 · THC 0mg / Self-Admin Dose: Oxycodone 15mg: 0 / 6 · THC 0mg / Self-Admin Dose: Oxycodone 45mg: 0 / 6 · THC 30mg / Self-Admin Dose: Oxycodone 0mg: 0 / 6 · THC 30mg / Self-Admin Dose: Oxycodone 15mg: 0 / 6 · THC 30mg / Self-Admin Dose: Oxycodone 45mg: 0 / 6 · Qualification Condition: THC 20mg / Oxycodone 0mg: 0 / 7 · Qualification Condition: THC 0mg / Oxycodone 30mg: 1 / 8 · Sample Condition: THC 0mg: 0 / 7 · Sample Condition: THC 10mg: 0 / 6 · Sample Condition: THC 30mg: 0 / 7 · Sample Condition: Oxycodone 0mg: 0 / 6 · Sample Condition: Oxycodone 15mg: 0 / 6 · Sample Condition: Oxycodone 45mg: 0 / 6 |
| Atheletes foot | Skin and subcutaneous tissue disorders | Pre-Intervention/Days Off: 0 / 8 · Oxycodone 0mg / Self-Admin Dose: THC 0mg: 0 / 7 · Oxycodone 0mg / Self-Admin Dose: THC 10mg: 0 / 6 · Oxycodone 0mg / Self-Admin Dose: THC 30mg: 0 / 7 · Oxycodone 45mg / Self-Admin Dose: THC 0mg: 0 / 7 · Oxycodone 45mg / Self-Admin Dose: THC 10mg: 0 / 6 · Oxycodone 45mg / Self-Admin Dose: THC 30mg: 0 / 6 · THC 0mg / Self-Admin Dose: Oxycodone 0mg: 0 / 6 · THC 0mg / Self-Admin Dose: Oxycodone 15mg: 0 / 6 · THC 0mg / Self-Admin Dose: Oxycodone 45mg: 0 / 6 · THC 30mg / Self-Admin Dose: Oxycodone 0mg: 0 / 6 · THC 30mg / Self-Admin Dose: Oxycodone 15mg: 0 / 6 · THC 30mg / Self-Admin Dose: Oxycodone 45mg: 0 / 6 · Qualification Condition: THC 20mg / Oxycodone 0mg: 0 / 7 · Qualification Condition: THC 0mg / Oxycodone 30mg: 0 / 8 · Sample Condition: THC 0mg: 0 / 7 · Sample Condition: THC 10mg: 0 / 6 · Sample Condition: THC 30mg: 1 / 7 · Sample Condition: Oxycodone 0mg: 0 / 6 · Sample Condition: Oxycodone 15mg: 0 / 6 · Sample Condition: Oxycodone 45mg: 0 / 6 |