INTERVENTIONALACTIVE NOT RECRUITINGNCT05335252

Dronabinol for the Treatment of Postoperative Pain After Arthroscopic Surgery: a Pilot Randomized Trial

The purpose of the proposed study is to evaluate the efficacy of dronabinol for postoperative pain after arthroscopic surgery of the knee. The investigators hypothesize that dronabinol will relieve pain, reduce opioid consumption and will result in few negative side effects. If this pilot study shows promising results the investigators will expand the trial to include additional arthroscopic surgeries (hip, shoulder) and other types of orthopaedic surgery.

Locally preserved from ClinicalTrials.govOpen ClinicalTrials.govlast source update 2026-05-27

What this record can show

Protocol only - no registry results posted

This locally preserved record separates the registered protocol from source-reported registry results. Neither is a treatment recommendation.

Registry facts

Study at a glance

Phase: PHASE3
Enrollment: 30 (ESTIMATED)
Start date: 2022-06-28
Sponsor: Northwestern University
Design: RANDOMIZED · PARALLEL · TREATMENT
Locations: 1
Results record: Not present in registry snapshot

Linked local records

Related local records

Local links use governed condition terms or exact source-reported intervention names. They are navigation candidates, not efficacy claims.

Conditions

No published condition report matched.

Cannabinoids and active compounds

Delta(9)-tetrahydrocannabinol

Medicines

DRONABINOL DRONABINOL DRONABINOL DRONABINOL MARINOL Marinol MARINOL

Interventions

What was registered

DRUG

Dronabinol

5mg 2x daily for 7 days

Marinol

DRUG

Placebo

1 caplet 2x daily for 7 days

Eligibility

Population and criteria

Sex: ALL
Minimum age: 18 Years
Maximum age: Not reported
Healthy volunteers: Not accepted

Inclusion criteria

Age 18 years or older
Patient who will undergo arthroscopic surgery of the knee including, but not limited to,
Meniscectomy
Synovectomy
Chondroplasty
Loose body removal

Exclusion criteria

Patients under age 18 years
Patients who cannot provide consent
Patients who are pregnant, breast feeding, or are trying to become pregnant during the study period
Patients with an allergy to any of the study drugs
Patient who are lactose-intolerant
Revision surgery
Open surgery
Comorbidities preventing surgery
Patients with a history of mania, depression, or schizophrenia
Patients taking any of the following drugs or supplements
Anticholinergic agents
Benzodiazepines
Central nervous system depressants
Droperidol
Hydroxyzine
Levomepromazine or methotrimeprazine
Monoamine oxidase inhibitors
Ritonavir
Selective serotonin reuptake inhibitors
Sympathomimetics
St. John's Wort
Current diagnosed alcohol or drug abuse
Patients who cannot or will not abide by the medication restrictions listed below Medication restrictions
Participants must agree to abstain from using recreational or medical marijuana products or cannabidiol (CBD) in any form during the treatment period
Participants should not drink alcohol or take other drugs while taking the study drug or hydrocodone/acetaminophen

primary outcomes

primary measures

Opioid consumption

Time frame: up to 7 days post-surgery

Count of number of hydrocodone/acetaminophen tablet consumed

secondary outcomes

secondary measures

Pain Visual Analog Scale (VAS)

Time frame: up to 7 days post-surgery

Scored from 0 (no pain) to 10 (worst possible pain)

Patient-Reported Outcomes Measurement Information System (PROMIS) Bank v1.1 - Pain Interference

Time frame: up to 21 days post-surgery

PROMIS measures generate T-scores. T-scores are standard scores with a mean of 50 and standard deviation of 10 in a reference population (usually U.S. general population). A low score indicates less pain interference (better outcome) and a high score indicates more pain interference (worse outcome).

PROMIS Bank v2.0 - Pain Behavior

Time frame: up to 21 days post-surgery

PROMIS measures generate T-scores. T-scores are standard scores with a mean of 50. A low score indicates less pain (better outcome) and a high score indicates more pain (worse outcome).

PROMIS Bank v2.0 - Physical Function

Time frame: up to 21 days post-surgery

PROMIS measures generate T-scores. T-scores are standard scores with a mean of 50. A low score indicates worse physical functioning and a high score indicates better physical functioning.

Publications

Locally readable linked articles

No exact PMID-linked public article is currently readable locally.

Snapshot provenance

Snapshot: 04701ca2-04ab-4945-9b80-2466d856e22b
Retrieved: 11/09/2026, 14:15:22
SHA-256: ed047832a924fb67a070e0a659b7e666b4448ccc2a3f92674dcbcf260201a440