INTERVENTIONALCOMPLETEDNCT05170217

Reducing the Harmful Effects of Cannabis Use: Finding the Optimal CBD:THC Ratio

This study will recruit healthy volunteers who use cannabis infrequently. Each participant will attend the laboratory on five occasions: an initial visit to check that they are safe to join the study and four days of testing. Participants will be administered, in a randomized order, vaporized cannabis containing one of four different ratios of CBD:THC (0:1, 1:1, 2:1, 3:1). The cannabis administration will follow a standardised inhalation procedure using a medical-grade vaporizer device. Participants will complete a series of tasks measuring cognition, psychosis, anxiety and other subjective experiences. The study will be carried out at the NIHR-Wellcome Trust Clinical Research Facility at King's College Hospital.

Locally preserved from ClinicalTrials.govOpen ClinicalTrials.govlast source update 2021-12-27

What this record can show

Protocol only - no registry results posted

This locally preserved record separates the registered protocol from source-reported registry results. Neither is a treatment recommendation.

Registry facts

Study at a glance

Phase: NA
Enrollment: 46 (ACTUAL)
Start date: 2017-11-08
Sponsor: King's College London
Design: RANDOMIZED · CROSSOVER · BASIC SCIENCE
Locations: 1
Results record: Not present in registry snapshot

Linked local records

Related local records

Local links use governed condition terms or exact source-reported intervention names. They are navigation candidates, not efficacy claims.

Conditions

No published condition report matched.

Cannabinoids and active compounds

cannabidiol Delta(9)-tetrahydrocannabinol

Medicines

No exact medicine-name link was found.

Research network

Researchers and organizations

Alex Dickens Amedeo Minichino Amir Englund Dominic Oliver Edward Chesney Jack McLeod Wilson John Hodsoll John Strang Lucy Chester Matej Oresic

secondary measures

Hopkins Verbal Learning Task

Time frame: 20-40 minutes post cannabis inhalation

Immediate verbal recall

Forward and Reverse Digit span

Time frame: 20-40 minutes post cannabis inhalation

Working memory

Spatial N-back task

Time frame: 20-40 minutes post cannabis inhalation

Spatial working memory

Positive and Negative Syndrome Scale

Time frame: Baseline; 3-4 hours post cannabis inhalation

Positive subscale

State Social Paranoia Scale

Time frame: 3-4 hours post cannabis inhalation

Community assessment of Psychic Experiences - state

Time frame: 3-4 hours post cannabis inhalation

Psychotomimetic states inventory

Time frame: 3-4 hours post cannabis inhalation

Visual analogue scales (0 to 100 millimetres)

Time frame: Baseline; Pre-cannabis, 10 minutes post-cannabis, 50 minutes post-cannabis, 1 hour 10 minutes post-cannabis, discharge

* Feel drug effect * Like drug effect * Want more drug * Mentally impaired * Dry Mouth * Enhanced colour perception * Enhanced sound perception * Want food * Want alcohol * Feel high * Feel anxious * Feel paranoid * Feel tired * Feel calm and relaxed * Feel stoned * The drug effects are pleasurable