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The purpose of the study is to develop and test innovative interventions to prevent the development of opioid misuse and opioid use disorders among older adolescents and young adults (AYA; ages 16-30) who use opioids, which will be initiated from a health care visit in the emergency department and extended post discharge via a telehealth approach. This study will have significant impact by identifying optimal, cost-effective opioid prevention strategies to sustain outcomes among AYAs.
Locally preserved from ClinicalTrials.govOpen ClinicalTrials.govlast source update 2026-08-25
What this record can show
Results are reported by the registry submitter and preserved exactly. They are not independent verification or a treatment recommendation.
Registry facts
Linked local records
Local links use governed condition terms or exact source-reported intervention names. They are navigation candidates, not efficacy claims.
Interventions
A remote brief intervention delivered by health coaches that uses Motivational Interviewing to address opioid misuse and risk factors. Remote health coaches use a web-based clinician support guide to maintain fidelity, while tailoring the session to unique participant factors.
Remote health coaches will push tailored messages to participants over a 4-week period. The messages will use Motivational Interviewing strategies. The messages are designed to elicit a response from the participant. Health coaches will also respond to participant replies consistent with Motivational Interviewing over a course of 4 weeks.
The brochure covers educational topics like opioid storage and disposal and overdose prevention, as well as resources such as naloxone, suicide hotlines, mental health, and substance use treatment. It will be available online and in print.
Source-reported results
Results are reported by the registry submitter and preserved exactly. They are not independent verification or a treatment recommendation.
Alcohol Smoking and Substance Involvement Screening Test severity risk score (severity of prescription opioids/heroin consumption and consequences, scores range 0-27 per subscale; the prescription opioid and heroin subscales are summed such that total possible range on this measure is 0-54, higher score indicates worse outcomes/more severity). Note: missing data was imputed and median scores are presented.
| Group | N | Value | Spread / interval |
|---|---|---|---|
| Brief Intervention (BI) Then Portal | 284 | 0 | 0 to 0 |
| Brief Intervention (BI) Then Enhanced Usual Care (EUC) | 286 | 0 | 0 to 0 |
| Enhanced Usual Care (EUC) Then Portal | 295 | 0 | 0 to 0 |
| Enhanced Usual Care (EUC) Then EUC | 290 | 0 | 0 to 0 |
| Brief Intervention (BI) Then Portal | 284 | 0 | 0 to 0 |
| Brief Intervention (BI) Then Enhanced Usual Care (EUC) | 286 | 0 | 0 to 0 |
| Enhanced Usual Care (EUC) Then Portal | 295 | 0 | 0 to 0 |
| Enhanced Usual Care (EUC) Then EUC | 290 | 0 | 0 to 0 |
| Brief Intervention (BI) Then Portal | 284 | 0 | 0 to 0 |
| Brief Intervention (BI) Then Enhanced Usual Care (EUC) | 286 |
Eligibility
primary outcomes
Time frame: 3, 6, and 12 months
Alcohol Smoking and Substance Involvement Screening Test severity risk score (severity of prescription opioids/heroin consumption and consequences, scores range 0-27 per subscale; the prescription opioid and heroin subscales are summed such that total possible range on this measure is 0-54, higher score indicates worse outcomes/more severity). Note: missing data was imputed and median scores are presented.
secondary outcomes
Time frame: 3, 6, and 12 months
Opioid-related risk behaviors (score ranges from 0-32, higher score indicates worse outcomes)
Time frame: 3, 6, and 12 months
Item based on the Addiction Severity Index (modified), data was collected for days of opioid misuse and possible scores ranged from 0-60. For statistical analysis, responses were dichotomized to 0 days vs. 1+ days, thus results are presented as # of participants reporting past 30-day opioid misuse.
Time frame: 3, 6, and 12 months
Substance use severity index (based on 7-items measuring frequency of: alcohol consumption, cannabis consumption, prescription sedative misuse, prescription stimulant misuse, cocaine consumption, methamphetamine consumption, hallucinogens consumption), sum of all 7 items with response options for each substance: 0 = never, 1= 1 time, 2= 2 times, 3= Once a month, 4= 2 to 3 times a month, 5= Once a week, 6= 2 times a week, 7= 3 to 4 times a week, 8= Nearly every day, 9= Every day, 10= More than once a day; total possible range is 0-70, higher scores indicate worse outcome/greater severity
Time frame: 3, 6, and 12 months
Adapted alcohol (14 items), cannabis (14 items), and/or opioid-related consequences (14 items); response options for each item on each subscale were: 0=Never, 1=1 time, 2=2 times, 3=3-5 times, 4=6-9 times, 5=10-19 times, 6=20 or more times. Measure comprises total of sum of items across 3 subscales with a possible range of 0 to 252, higher score indicates worse outcomes/more consequences
Time frame: 3, 6, and 12 months
Adapted items from Young Adult Driving Questionnaire (5 items; score ranges from 0-30; higher score indicates worse outcome)
Publications
No exact PMID-linked public article is currently readable locally.
| 0 |
| 0 to 0 |
| Enhanced Usual Care (EUC) Then Portal | 295 | 0 | 0 to 0 |
| Enhanced Usual Care (EUC) Then EUC | 290 | 0 | 0 to 0 |
| Brief Intervention (BI) Then Portal | 284 | 0 | 0 to 0 |
| Brief Intervention (BI) Then Enhanced Usual Care (EUC) | 286 | 0 | 0 to 0 |
| Enhanced Usual Care (EUC) Then Portal | 295 | 0 | 0 to 0 |
| Enhanced Usual Care (EUC) Then EUC | 290 | 0 | 0 to 0 |
Opioid-related risk behaviors (score ranges from 0-32, higher score indicates worse outcomes)
| Group | N | Value | Spread / interval |
|---|---|---|---|
| Brief Intervention (BI) Then Portal | 284 | 0 | 0 to 0 |
| Brief Intervention (BI) Then Enhanced Usual Care (EUC) | 286 | 0 | 0 to 0 |
| Enhanced Usual Care (EUC) Then Portal | 295 | 0 | 0 to 1 |
| Enhanced Usual Care (EUC) Then EUC | 290 | 0 | 0 to 0 |
| Brief Intervention (BI) Then Portal | 284 | 0 | 0 to 0 |
| Brief Intervention (BI) Then Enhanced Usual Care (EUC) | 286 | 0 | 0 to 0 |
| Enhanced Usual Care (EUC) Then Portal | 295 | 0 | 0 to 0 |
| Enhanced Usual Care (EUC) Then EUC | 290 | 0 | 0 to 0 |
| Brief Intervention (BI) Then Portal | 284 | 0 | 0 to 0 |
| Brief Intervention (BI) Then Enhanced Usual Care (EUC) | 286 | 0 | 0 to 0 |
| Enhanced Usual Care (EUC) Then Portal | 295 | 0 | 0 to 0 |
| Enhanced Usual Care (EUC) Then EUC | 290 | 0 | 0 to 0 |
| Brief Intervention (BI) Then Portal | 284 | 0 | 0 to 0 |
| Brief Intervention (BI) Then Enhanced Usual Care (EUC) | 286 | 0 | 0 to 0 |
| Enhanced Usual Care (EUC) Then Portal | 295 | 0 | 0 to 0 |
| Enhanced Usual Care (EUC) Then EUC | 290 | 0 | 0 to 0 |
Item based on the Addiction Severity Index (modified), data was collected for days of opioid misuse and possible scores ranged from 0-60. For statistical analysis, responses were dichotomized to 0 days vs. 1+ days, thus results are presented as # of participants reporting past 30-day opioid misuse.
| Group | N | Value | Spread / interval |
|---|---|---|---|
| Brief Intervention (BI) Then Portal | 284 | 13 | - |
| Brief Intervention (BI) Then Enhanced Usual Care (EUC) | 286 | 14 | - |
| Enhanced Usual Care (EUC) Then Portal | 295 | 20 | - |
| Enhanced Usual Care (EUC) Then EUC | 290 | 15 | - |
| Brief Intervention (BI) Then Portal | 284 | 6 | - |
| Brief Intervention (BI) Then Enhanced Usual Care (EUC) | 286 | 11 | - |
| Enhanced Usual Care (EUC) Then Portal | 295 | 10 | - |
| Enhanced Usual Care (EUC) Then EUC | 290 | 3 | - |
| Brief Intervention (BI) Then Portal | 284 | 11 | - |
| Brief Intervention (BI) Then Enhanced Usual Care (EUC) | 286 | 6 | - |
| Enhanced Usual Care (EUC) Then Portal | 295 | 13 | - |
| Enhanced Usual Care (EUC) Then EUC | 290 | 5 | - |
| Brief Intervention (BI) Then Portal | 284 | 17 | - |
| Brief Intervention (BI) Then Enhanced Usual Care (EUC) | 286 | 7 | - |
| Enhanced Usual Care (EUC) Then Portal | 295 | 7 | - |
| Enhanced Usual Care (EUC) Then EUC | 290 | 4 | - |
Substance use severity index (based on 7-items measuring frequency of: alcohol consumption, cannabis consumption, prescription sedative misuse, prescription stimulant misuse, cocaine consumption, methamphetamine consumption, hallucinogens consumption), sum of all 7 items with response options for each substance: 0 = never, 1= 1 time, 2= 2 times, 3= Once a month, 4= 2 to 3 times a month, 5= Once a week, 6= 2 times a week, 7= 3 to 4 times a week, 8= Nearly every day, 9= Every day, 10= More than once a day; total possible range is 0-70, higher scores indicate worse outcome/greater severity
| Group | N | Value | Spread / interval |
|---|---|---|---|
| Brief Intervention (BI) Then Portal | 284 | 8 | 4 to 12 |
| Brief Intervention (BI) Then Enhanced Usual Care (EUC) | 286 | 6.5 | 4 to 11 |
| Enhanced Usual Care (EUC) Then Portal | 295 | 6 | 4 to 10 |
| Enhanced Usual Care (EUC) Then EUC | 290 | 7 | 4 to 11 |
| Brief Intervention (BI) Then Portal | 284 | 7 | 4 to 11 |
| Brief Intervention (BI) Then Enhanced Usual Care (EUC) | 286 | 7 | 4 to 11 |
| Enhanced Usual Care (EUC) Then Portal | 295 | 6 | 3 to 10 |
| Enhanced Usual Care (EUC) Then EUC | 290 | 7 | 4 to 11 |
| Brief Intervention (BI) Then Portal | 284 | 7 | 4 to 11 |
| Brief Intervention (BI) Then Enhanced Usual Care (EUC) | 286 | 7 | 4 to 11 |
| Enhanced Usual Care (EUC) Then Portal | 295 | 6 | 3 to 10 |
| Enhanced Usual Care (EUC) Then EUC | 290 | 7 | 3 to 11 |
| Brief Intervention (BI) Then Portal | 284 | 7 | 4 to 11 |
| Brief Intervention (BI) Then Enhanced Usual Care (EUC) | 286 | 6.5 | 4 to 11 |
| Enhanced Usual Care (EUC) Then Portal | 295 | 6 | 2 to 10 |
| Enhanced Usual Care (EUC) Then EUC | 290 | 7 | 4 to 11 |
Adapted alcohol (14 items), cannabis (14 items), and/or opioid-related consequences (14 items); response options for each item on each subscale were: 0=Never, 1=1 time, 2=2 times, 3=3-5 times, 4=6-9 times, 5=10-19 times, 6=20 or more times. Measure comprises total of sum of items across 3 subscales with a possible range of 0 to 252, higher score indicates worse outcomes/more consequences
| Group | N | Value | Spread / interval |
|---|---|---|---|
| Brief Intervention (BI) Then Portal | 284 | 12.5 | 4 to 27 |
| Brief Intervention (BI) Then Enhanced Usual Care (EUC) | 286 | 12 | 3 to 23 |
| Enhanced Usual Care (EUC) Then Portal | 295 | 12 | 4 to 25 |
| Enhanced Usual Care (EUC) Then EUC | 290 | 11.5 | 3 to 22 |
| Brief Intervention (BI) Then Portal | 284 | 6 | 1 to 20 |
| Brief Intervention (BI) Then Enhanced Usual Care (EUC) | 286 | 6 | 1 to 17 |
| Enhanced Usual Care (EUC) Then Portal | 295 | 6 | 1 to 19 |
| Enhanced Usual Care (EUC) Then EUC | 290 | 6 | 1 to 16 |
| Brief Intervention (BI) Then Portal | 284 | 5 | 1 to 16 |
| Brief Intervention (BI) Then Enhanced Usual Care (EUC) | 286 | 5 | 1 to 15 |
| Enhanced Usual Care (EUC) Then Portal | 295 | 6 | 1 to 15 |
| Enhanced Usual Care (EUC) Then EUC | 290 | 6 | 1 to 17 |
| Brief Intervention (BI) Then Portal | 284 | 5 | 0 to 15 |
| Brief Intervention (BI) Then Enhanced Usual Care (EUC) | 286 | 6 | 0 to 16 |
| Enhanced Usual Care (EUC) Then Portal | 295 | 5 | 0 to 15 |
| Enhanced Usual Care (EUC) Then EUC | 290 | 5 | 0 to 15 |
Adapted items from Young Adult Driving Questionnaire (5 items; score ranges from 0-30; higher score indicates worse outcome)
| Group | N | Value | Spread / interval |
|---|---|---|---|
| Brief Intervention (BI) Then Portal | 284 | 0 | 0 to 2 |
| Brief Intervention (BI) Then Enhanced Usual Care (EUC) | 286 | 0 | 0 to 2 |
| Enhanced Usual Care (EUC) Then Portal | 295 | 0 | 0 to 3 |
| Enhanced Usual Care (EUC) Then EUC | 290 | 0 | 0 to 2 |
| Brief Intervention (BI) Then Portal | 284 | 0 | 0 to 1 |
| Brief Intervention (BI) Then Enhanced Usual Care (EUC) | 286 | 0 | 0 to 1 |
| Enhanced Usual Care (EUC) Then Portal | 295 | 0 | 0 to 1 |
| Enhanced Usual Care (EUC) Then EUC | 290 | 0 | 0 to 1 |
| Brief Intervention (BI) Then Portal | 284 | 0 | 0 to 1 |
| Brief Intervention (BI) Then Enhanced Usual Care (EUC) | 286 | 0 | 0 to 0 |
| Enhanced Usual Care (EUC) Then Portal | 295 | 0 | 0 to 1 |
| Enhanced Usual Care (EUC) Then EUC | 290 | 0 | 0 to 1 |
| Brief Intervention (BI) Then Portal | 284 | 0 | 0 to 1 |
| Brief Intervention (BI) Then Enhanced Usual Care (EUC) | 286 | 0 | 0 to 1 |
| Enhanced Usual Care (EUC) Then Portal | 295 | 0 | 0 to 1 |
| Enhanced Usual Care (EUC) Then EUC | 290 | 0 | 0 to 0 |
N/A, randomization was the point of enrollment in this study.
| Milestone | Brief Intervention (BI) Then Portal | Brief Intervention (BI) Then Enhanced Usual Care (EUC) | Enhanced Usual Care (EUC) Then Portal | Enhanced Usual Care (EUC) Then EUC |
|---|---|---|---|---|
| STARTED | 284 | 286 | 295 | 290 |
| COMPLETED | 284 | 286 | 295 | 290 |
| NOT COMPLETED | 0 | 0 | 0 | 0 |
| Milestone | Brief Intervention (BI) Then Portal | Brief Intervention (BI) Then Enhanced Usual Care (EUC) | Enhanced Usual Care (EUC) Then Portal | Enhanced Usual Care (EUC) Then EUC |
|---|---|---|---|---|
| STARTED | 284 | 286 | 295 | 290 |
| Assigned to BI Then Enhanced Usual Care; but Completed BI Then Portal by Mistake | 1 | 0 | 0 | 0 |
| COMPLETED | 260 | 259 | 294 | 290 |
| NOT COMPLETED | 24 | 27 | 1 | 0 |
| Milestone | Brief Intervention (BI) Then Portal | Brief Intervention (BI) Then Enhanced Usual Care (EUC) | Enhanced Usual Care (EUC) Then Portal | Enhanced Usual Care (EUC) Then EUC |
|---|---|---|---|---|
| STARTED | 284 | 286 | 295 | 290 |
| COMPLETED | 250 | 259 | 266 | 274 |
| NOT COMPLETED | 34 | 27 | 29 | 16 |
| Milestone | Brief Intervention (BI) Then Portal | Brief Intervention (BI) Then Enhanced Usual Care (EUC) | Enhanced Usual Care (EUC) Then Portal | Enhanced Usual Care (EUC) Then EUC |
|---|---|---|---|---|
| STARTED | 284 | 286 | 295 | 290 |
| COMPLETED | 241 | 250 | 270 | 272 |
| NOT COMPLETED | 43 | 36 | 25 | 18 |
| Milestone | Brief Intervention (BI) Then Portal | Brief Intervention (BI) Then Enhanced Usual Care (EUC) | Enhanced Usual Care (EUC) Then Portal | Enhanced Usual Care (EUC) Then EUC |
|---|---|---|---|---|
| STARTED | 284 | 286 | 295 | 290 |
| COMPLETED | 227 | 242 | 265 | 264 |
| NOT COMPLETED | 57 | 44 | 30 | 26 |
| Event | System | Groups: affected / at risk |
|---|---|---|
| Hospitalization | General disorders | Brief Intervention (BI) Then Portal: 9 / 284 · Brief Intervention (BI) Then Enhanced Usual Care (EUC): 0 / 286 · Enhanced Usual Care (EUC) Then Portal: 2 / 295 · Enhanced Usual Care (EUC) Then EUC: 0 / 290 |
| Death | General disorders | Brief Intervention (BI) Then Portal: 3 / 284 · Brief Intervention (BI) Then Enhanced Usual Care (EUC): 2 / 286 · Enhanced Usual Care (EUC) Then Portal: 0 / 295 · Enhanced Usual Care (EUC) Then EUC: 1 / 290 |
| Hospitalization | Surgical and medical procedures | Brief Intervention (BI) Then Portal: 2 / 284 · Brief Intervention (BI) Then Enhanced Usual Care (EUC): 0 / 286 · Enhanced Usual Care (EUC) Then Portal: 3 / 295 · Enhanced Usual Care (EUC) Then EUC: 2 / 290 |
| Hospitalization | Gastrointestinal disorders | Brief Intervention (BI) Then Portal: 0 / 284 · Brief Intervention (BI) Then Enhanced Usual Care (EUC): 0 / 286 · Enhanced Usual Care (EUC) Then Portal: 3 / 295 · Enhanced Usual Care (EUC) Then EUC: 0 / 290 |
| Hospitalization | Cardiac disorders | Brief Intervention (BI) Then Portal: 0 / 284 · Brief Intervention (BI) Then Enhanced Usual Care (EUC): 0 / 286 · Enhanced Usual Care (EUC) Then Portal: 1 / 295 · Enhanced Usual Care (EUC) Then EUC: 0 / 290 |
| Hospitalization | Infections and infestations | Brief Intervention (BI) Then Portal: 1 / 284 · Brief Intervention (BI) Then Enhanced Usual Care (EUC): 1 / 286 · Enhanced Usual Care (EUC) Then Portal: 0 / 295 · Enhanced Usual Care (EUC) Then EUC: 0 / 290 |
| Hospitalization | Psychiatric disorders | Brief Intervention (BI) Then Portal: 2 / 284 · Brief Intervention (BI) Then Enhanced Usual Care (EUC): 2 / 286 · Enhanced Usual Care (EUC) Then Portal: 5 / 295 · Enhanced Usual Care (EUC) Then EUC: 4 / 290 |
| Death | Psychiatric disorders | Brief Intervention (BI) Then Portal: 0 / 284 · Brief Intervention (BI) Then Enhanced Usual Care (EUC): 0 / 286 · Enhanced Usual Care (EUC) Then Portal: 1 / 295 · Enhanced Usual Care (EUC) Then EUC: 0 / 290 |
| Event | System | Groups: affected / at risk |
|---|---|---|
| Emergency Visit | General disorders | Brief Intervention (BI) Then Portal: 0 / 284 · Brief Intervention (BI) Then Enhanced Usual Care (EUC): 0 / 286 · Enhanced Usual Care (EUC) Then Portal: 1 / 295 · Enhanced Usual Care (EUC) Then EUC: 0 / 290 |