Treating Nightmares in Posttraumatic Stress Disorder With Dronabinol: A Randomized Controlled Study (THC PTSD-trial)

Exclusion criteria

• 1. Lifetime cannabis use disorder 2. Current substance/alcohol use disorder (≤ 3 months); 3. Acute suicidality; 4. Psychotic disorder; 5. Bipolar disorder; 6. Current anorexia nervosa; 7. Current major depressive episodes and a MADRS score \> 29; 8. Dementia; 9. Trauma-focused psychotherapy four weeks before the trial 10. Initiation of sleep medication 4 weeks prior screening or initiation of alpha adrenergic agents 4 weeks prior to screening 11. Acute or unstable medical illness. 12. Epilepsy 13. Relevant heart diseases 14. Known HIV- and/or active Hepatitis-B- or Hepatitis-C-infection 15. Current or past malignant illness 16. The patient is unwilling to consent to saving, processing and propagation of pseudonymized medical data for study reasons 17. Patients, who may be dependent on the sponsor, the investigator or the trial sites, have to be excluded from the trial 18. The patient is legally detained in an official institution 19. The patient does have a known allergy or contraindication against Dronabinol 20. The patient does have clinically significant abnormalities in 12-lead ECG 21. The patient does have clinically significant laboratory abnormalities 22. The patient did participate in other interventional trials during the 3 months before and at the time of this trial