Investigating the Effect of Dronabinol on Post-surgical Pain

Registry facts

Study at a glance

Phase

EARLY PHASE1

Enrollment

0 (ACTUAL)

Start date

2025-09-01

Sponsor

New York State Psychiatric Institute

Design

RANDOMIZED · PARALLEL · TREATMENT

Locations

1

Results record

Not present in registry snapshot

Total knee replacement is a common surgical procedure that restores function to the damaged joint. Recovery from this procedure takes weeks and requires opioids to manage post-surgical pain. The goal of this study is to investigate whether dronabinol (synthetic THC) can reduce pain and the need for opioid medication following this particular surgery. Subjects will be recruited from the Department of Orthopedic Surgery. All subjects will undergo total knee replacement as part of their clinical care (the surgery itself is not part of this study). The study begins following discharge from the hospital. They will be asked to take dronabinol or placebo as they recover from surgery. During this time they will be given their usual pain medications at discharge which includes opioids for pain. The opioids are to be taken if the subject is experiencing pain. The investigator's hypothesis is that subjects taking dronabinol will need fewer doses of opioids to control pain.