Tai chi exercise
24-form Yang style Tai Chi (60 min/session, 3 sessions/week) for 8 weeks
Loading study record…
Loading study record…
This study is to determine how 8-week Tai Chi intervention alters plasma endocannabinoid and its receptors in monocytes/marcrophages, plasma oxylipinds, plasma brain-derived neurotrophic factor, brain white matter connectivity/efficiency, and functional/clinical outcomes in women with knee OA.
Locally preserved from ClinicalTrials.govOpen ClinicalTrials.govlast source update 2025-03-28
What this record can show
This locally preserved record separates the registered protocol from source-reported registry results. Neither is a treatment recommendation.
Registry facts
Knee osteoarthritis (OA) is one of the five leading causes of disability. Previous studies have shown that a mind-body moderate-intensity Tai Chi (TC) exercise (8-24 weeks) reduced pain and improved physical function for knee OA, when compared to a waiting list, attention control, usual physical activity, or physical therapy. However, TC's mechanisms of action regarding improvement of one's clinical condition and its functional outcomes in individuals with knee OA are poorly understood. This study is to determine how 8-week TC intervention alters plasma endocannabinoid and its receptors in monocytes/marcrophages, plasma oxylipinds, plasma brain-derived neurotrophic factor, brain white matter connectivity/efficiency, and functional/clinical outcomes in women with knee OA.
Linked local records
Local links use governed condition terms or exact source-reported intervention names. They are navigation candidates, not efficacy claims.
Research network
Interventions
24-form Yang style Tai Chi (60 min/session, 3 sessions/week) for 8 weeks
Eligibility
primary outcomes
Time frame: Changes from bseline endocannabinoid levels at 8 weeks
plasma endocannabinoid levels
Time frame: Changes from baseline oxylipins levels at 8 weeks
plasma oxylipins levels
secondary outcomes
Time frame: Changes from baseline the affinity of endocannabinoid receptor expression at 8 weeks
expression of endocannabinoids receptors on peripheral blood mononuclear cells using flow cytometry. Collect venous blood into evacuated tube containing lithium heparin and pour into a Leucosep tube prepared with Ficoll-Paque. Following sequential centrifugation steps, peripheral blood mononuclear cells will be collected and incubate with endotoxin (e.g. LPS or PMA) for 24 hours (Venable 2016). After incubation, PBMC will be collected and stained with cannabinoid receptors (CB1R and CB2R) and markers for monocytes/macrophages (CD14, etc).
Time frame: Changes from baseline BDNF levels at 8 weeks
plasma brain-derived neurotrophic factor levels using ELISA
Time frame: Change from baselinewhite matter connectivity/efficiency of various fiber tracts in the brain at 8 weeks
We will follow the protocol of Vachon-Presseau et al. 2006 to collect DTI data. DTI images will be acquired using echo planar imaging (72 x 2-mm thick axial slices; matrix size = 128 x 128; field of view = 256 x 256mm2, resulting in a voxel size of 2 x 2 x 2mm). Images will have an isotropic distribution along 60 directions using a b-value of 1000s/mm2. For each set of diffusion-weighted data, eight volumes with no diffusion weighting will be acquired at equidistant points throughout the acquisition.
Time frame: Change from baseline pain sensitivity scale at 8 weeks
We will use quantitative sensory test including windup to assess pain sensitivity in the most painful knee of subject
Time frame: Change from baseline pain scale at 8 weeks
We will use Brief Pain Inventory (questionnaire) for pain assessment.
Time frame: Changes from baseline WOMAC results at 8 weeks
We will use WOAMC questionnaire for physical function assessment
Time frame: Changes from baseline SF-36 results at 8 weeks
Quality of life status will be assessed with the Medical Outcomes Study 36-item short form Health Survey (SF-36, version 2), which consists of eight dimensions of health (physical function, bodily pain, general health, vitality, mental health, social function, and role of physical and emotional health) in the conduct of daily activity characteristics will be assessed with self-report SF-36 questionnaires related to self-rated health, depression, anxiety and sleep quality.
Publications