INTERVENTIONALCOMPLETEDNCT03471585

The Effects of Δ⁹-Tetrahydrocannabinol on the Retrieval of Emotional Memories

The main purpose of this study was to examine the effects of THC on the retrieval of emotional and neutral memories in healthy young adults. Secondary experiments included the effects of THC on the encoding of object and scene stimuli and a novel working memory task.

Locally preserved from ClinicalTrials.govOpen ClinicalTrials.govlast source update 2019-05-30

What this record can show

Protocol only - no registry results posted

This locally preserved record separates the registered protocol from source-reported registry results. Neither is a treatment recommendation.

Registry facts

Study at a glance

Phase: EARLY PHASE1
Enrollment: 24 (ACTUAL)
Start date: 2017-02-15
Sponsor: University of Chicago
Design: RANDOMIZED · CROSSOVER · BASIC SCIENCE
Locations: 1
Results record: Not present in registry snapshot

Here, the investigators aimed to investigate the effects of THC (15 mg) on the retrieval of negative, neutral, and positive memories. The study used a placebo-controlled, within-subjects, crossover design with 24 participants. In each experimental arm, participants attend a session to encode stimuli, a second session 48 hours later in which their memories are tested for the stimuli from the first session followed by the encoding of object-scene stimuli and a working memory test, and a third session 48 hours later in which memory for the object-scene stimuli is tested. In the second session, two hours prior to memory testing, THC or placebo is administered. On the first and second sessions subjects complete mood questionnaires.

Linked local records

Related local records

Local links use governed condition terms or exact source-reported intervention names. They are navigation candidates, not efficacy claims.

Conditions

No published condition report matched.

Cannabinoids and active compounds

Delta(9)-tetrahydrocannabinol

Medicines

MARINOL Marinol MARINOL

Interventions

What was registered

DRUG

THC

A capsule that contains 15 mg of THC as well as dextrose filler administered 2 hours prior to memory testing.

Marinol

DRUG

Placebo oral capsule

A capsule that contains only dextrose filler administered 2 hours prior to memory testing.

Dextrose

Eligibility

Population and criteria

Sex: ALL
Minimum age: 18 Years
Maximum age: 35 Years
Healthy volunteers: Accepted

Inclusion criteria

4-100 lifetime cannabis occasions

Exclusion criteria

Current Axis I DSM-IV disorder, including substance dependence, current use of \>5 cigarettes per day, history of psychosis or mania, less than a high school education, lack of English fluency, a body mass index outside 19-33 kg/m2, high blood pressure (\>140/90), abnormal electrocardiogram, daily use of any medication other than birth control, pregnancy, or lactating.

primary outcomes

primary measures

Emotional Memory

Time frame: Two hours after placebo/THC administration.

Hit and false alarm rates for negative, neutral, and positive picture stimuli

DRM Memory

Time frame: Two and a half hours after placebo/THC administration.

Hit and false alarm rates for the DRM task

Object Memory

Time frame: 48 hours after placebo/THC administration.

Hit and false alarm rates for object stimuli on the same or different encoding scenes

secondary outcomes