Active Dronabinol
10 mg capsule of Dronabinol will be administered orally.
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The overarching goal of this study is to characterize the effects of ethanol and cannabinoids on simulated driving and related cognition.
Locally preserved from ClinicalTrials.govOpen ClinicalTrials.govlast source update 2026-04-27
What this record can show
This locally preserved record separates the registered protocol from source-reported registry results. Neither is a treatment recommendation.
Registry facts
To study the effects of ethanol clamped at BAC 0.04% (equivalent to consuming approximately 2 drinks over 1 hour) and oral Dronabinol (10 mg capsule) on driving.
Linked local records
Local links use governed condition terms or exact source-reported intervention names. They are navigation candidates, not efficacy claims.
Interventions
10 mg capsule of Dronabinol will be administered orally.
Control: no alcohol, administered for \~80 minutes.
Control: Placebo pill (no active cannabinoids) administered orally.
Target BrAC of 0.04% reached over 20 minutes and then clamped to maintain this dose for an additional 60 minutes. This dose is equivalent to consuming approximately 2 drinks over 1 hour. Administered over a total of 80 minutes.
Eligibility
primary outcomes
Time frame: baseline, +100, +210 mins after start of dronabinol administration
secondary outcomes
Time frame: baseline, +60, +90, +210, +360 mins after start of dronabinol administration
A scale designed to assess the stimulant and sedative effects associated with alcohol intoxication.
Time frame: baseline, +60, +90, +210, +360 mins after start of dronabinol administration
Feeling states associated with alcohol and cannabis intoxication will be measured using this self-report scale of feeling states.
Time frame: baseline, +120 mins after start of dronabinol administration
Several computer tasks will be administered to assess alcohol and THC effects on driving related cognition, including: visual vigilance, visual motor function, attention and working memory, and processing speed.
Time frame: baseline, +60, +90, +210, +360 mins after start of dronabinol administration
Subjects will be asked to rate their willingness to drive at their current state in the context of various scenarios including willingness to drive from testing facility to a number of destinations that are different driving distances.
Time frame: baseline, +60, +90, +210, +360 mins after start of dronabinol administration
Subjects will be asked to rate the number of standard joints that they believe they have been administered.
Time frame: baseline, +60, +90, +210, +360 mins after start of dronabinol administration
Subjects will be asked to rate the number of standard drinks that they believe they have been administered.
Publications
No exact PMID-linked public article is currently readable locally.