Active inhaled delta-9-THC
Low dose THC (\~4 mg), dissolved in alcohol. This dose is roughly equivalent to smoking approximately 1/4 of a marijuana cigarette, or "joint". Administered over 20 minutes via a vaporizer.
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The overarching goal of this study is to characterize the effects of ethanol and cannabinoids on simulated driving and related cognition.
Locally preserved from ClinicalTrials.govOpen ClinicalTrials.govlast source update 2026-04-29
What this record can show
This locally preserved record separates the registered protocol from source-reported registry results. Neither is a treatment recommendation.
Registry facts
To study the effects of oral ethanol (a target BAC of \~0.04 g/dl; equivalent to consuming approximately 2 drinks over 1 hour) and vaporized THC (4 mg of THC dissolved in an ethanolic solution; equivalent to smoking approximately 1/4 of a marijuana cigarette, or "joint") on driving.
Linked local records
Local links use governed condition terms or exact source-reported intervention names. They are navigation candidates, not efficacy claims.
Interventions
Low dose THC (\~4 mg), dissolved in alcohol. This dose is roughly equivalent to smoking approximately 1/4 of a marijuana cigarette, or "joint". Administered over 20 minutes via a vaporizer.
Control: Approximately 4 drinks of orange juice or ginger ale covered by a trace amount of ethanol on the surface, each administered over approximately 10 minutes.
Control: No active THC. Administered over 20 minutes via a vaporizer. approximately 10 minutes.
0.4 g/kg ethanol in orange juice or ginger ale to reach a target BrAC of approximately 0.04%. This dose is equivalent to consuming approximately 2 standard drinks over 1 hour. Approximately 4 drinks, each administered over approximately 10 minutes.
Eligibility
primary outcomes
Time frame: baseline, +20, +50, +120, +180 mins after start of alcohol administration
secondary outcomes
Time frame: baseline, +20, +50, +120, +180, +240 mins after start of alcohol administration
A scale designed to assess the stimulant and sedative effects associated with alcohol intoxication.
Time frame: baseline, +20, +50, +120, +180, +240 mins after start of alcohol administration
Feeling states associated with alcohol and cannabis intoxication will be measured using this self-report scale of feeling states.
Time frame: baseline, +20, +50, +120, +180, +240 mins after start of alcohol administration
Subjects will be asked to rate their willingness to drive at their current state in the context of various scenarios including willingness to drive from testing facility to a number of destinations that are different driving distances.
Time frame: +40 mins after start of alcohol administration
Several computer tasks will be administered to assess alcohol and THC effects on driving related cognition, including: visual vigilance, visual motor function, attention and working memory, and processing speed.
Time frame: baseline, +20, +50, +120, +180, +240 mins after start of alcohol administration
Subjects will be asked to rate the number of standard joints that they believe they have been administered.
Time frame: baseline, +20, +50, +120, +180, +240 mins after start of alcohol administration
Subjects will be asked to rate the number of standard drinks that they believe they have been administered.
Publications
No exact PMID-linked public article is currently readable locally.