Loading study record…
The overarching goal of this study is to characterize the effects of ethanol and cannabinoids on simulated driving and related cognition.
Locally preserved from ClinicalTrials.govOpen ClinicalTrials.govlast source update 2026-04-29
What this record can show
This locally preserved record separates the registered protocol from source-reported registry results. Neither is a treatment recommendation.
Registry facts
To study the effects of ethanol clamped at BAC 0.04% and THC (1.05 mg in a 70 kg individual) on driving.
Linked local records
Local links use governed condition terms or exact source-reported intervention names. They are navigation candidates, not efficacy claims.
Interventions
Low dose (0.015 mg/kg = 1.05 mg in a 70 kg individual) THC, dissolved in alcohol. This dose is roughly equivalent to smoking approximately 1/4 of a marijuana cigarette, or "joint". Administered over 20 minutes.
Control: small amount of alcohol (quarter teaspoon), with no THC. Administered over 20 minutes.
Target BrAC of 0.04% reached over 20 minutes and then clamped to maintain this dose for an additional 60 minutes. This dose is equivalent to consuming approximately 2 drinks over 1 hour. Administered over a total of 80 minutes.
Control: no alcohol, administered for a total of 80 minutes.
Eligibility
primary outcomes
Time frame: baseline, +20, +50, +120, +180 mins after start of alcohol and THC infusion
changes in road tracking errors between timepoints to assess the effects of alcohol and THC on road tracking errors.
secondary outcomes
Time frame: baseline, +20, +50, +120, +180, +240 mins after start of alcohol and THC infusion
A scale designed to assess the stimulant and sedative effects associated with alcohol intoxication.
Time frame: baseline, +20, +50, +120, +180 mins after start of alcohol and THC infusion
Feeling states associated with alcohol and cannabis intoxication will be measured using this self-report scale of feeling states.
Time frame: +40 mins after start of alcohol and THC infusion
Several computer tasks will be administered to assess alcohol and THC effects on driving related cognition, including: visual vigilance, visual motor function, attention and working memory, and processing speed.
Time frame: baseline, +20, +50, +120, +180 mins after start of alcohol and THC infusion
Subjects will be asked to rate their willingness to drive at their current state in the context of various scenarios including willingness to drive from testing facility to a number of destinations that are different driving distances.
Time frame: baseline, +20, +50, +120, +180 mins after start of alcohol and THC infusion
Subjects will be asked to rate the number of standard joints that they believe they have been administered.
Time frame: baseline, +20, +50, +120, +180 mins after start of alcohol and THC infusion
Subjects will be asked to rate the number of standard drinks that they believe they have been administered.
Publications
No exact PMID-linked public article is currently readable locally.