fMRI and Neurophysiological Study Protocol on Cannabinoids in Multiple Sclerosis

Exclusion criteria

• 1. Have a primary progressive MS 2. Patients under disease modifying therapies prescribed in the 6 months prior the study entry 3. Patients who have participated in another research study in the past 6 months 4. Changes in antispastic/antiepileptic treatments (dosage, frequency and route of administration) within one month prior the study entry 5. Have a psychiatric disorders or cognitive impairment that preclude safe participation in the study 6. Known history of alcohol or substance abuse 7. Concurrent clinically important immunologic, pulmonary, renal, liver, active thyroid, and/or other major disease other than MS 8. Severe cardiovascular, disorders, such as ischaemic heart disease, arrhythmias, poorly controlled hypertension or severe heart failure 9. Patients suffering from acute or chronic pain 10. History of epilepsy 11. Female patient who is pregnant, lactating or planning pregnancy during the course of the study 12. Scheduled elective surgery or other procedures requiring general anaesthesia during the study 13. Patient who is terminally ill or is inappropriate for placebo medication 14. Systemic corticosteroid therapy within 4 weeks of randomization or exacerbation of MS within 30 days 15. Regular levodopa therapy within 7 days of the study entry 16. Male patient currently receiving sildenafil (Viagra) and unwilling to stop medication for the duration of the study 17. Patients who are currently taking antiarrhythmic medications 18. Known or suspected adverse reaction to cannabinoids 19. Travel outside the Italy planned during the study 20. Donation of blood during the study 21. Contraindications to MRI scans -