Researcher profile

Jonathan Underwood

I am a consultant physician specialising in infectious diseases and acute/general internal medicine based at the University Hospital of Wales. I completed my PhD at Imperial College London in 2017 where I studied cognitive impairment in treated HIV-disease. My main research interest is understanding immunopathogenesis of infections, particularly the neurological sequelae of severe infections. I have an MRC-NIHR Clinical Academic Research Partnership grant to study blood-brain barrier dysfunction and cognitive outcomes following bloodstream infection. This work is in partnership with Prof Neil Harrison based at CUBRIC and the SAIL Databank at Swansea University and Public Health Wales. I am research lead for infectious diseases at Cardiff and Vale University Health Board, and principal investigator for several RCTs across a spectrum of infectious diseases (including community-acquired pneumonia, HIV & bloodstream infections). As Specialty Lead for Infection for Health and Care Research Wales I am to increase access and participation in clinical trials for patients across Wales.