Abstract Using novel mouse models, we establish cyclin-dependent kinase 12 (CDK12) as a bona fide tumor suppressor gene in tubo-ovarian…
Abstract Background: Lysine demethylase 4D (KDM4D or JMJD2D) plays a significant role in tumorigenesis, development, and poor clinical outcomes. However,…
Abstract Breast cancer significantly affects women’s lives globally. While PAX7 (Paired Box 7), a regulatory protein linked to muscle growth,…
Abstract Exhausted CD8+ T lymphocytes and tumor-associated macrophages play critical roles in determining cancer prognosis and the efficacy of immunotherapy.…
Abstract HD-Zip (Homeodomain-Leucine Zipper) is a family of transcription factors unique to higher plants and plays a vital role in…
Abstract Background: Recent evidence increasingly suggests key roles for the tricarboxylic acid cycle and fatty acid metabolism in tumor progression…
Abstract Background: The use of cannabis has increased globally due to more regions decriminalizing marijuana use for therapeutic and recreational…
Abstract Dysregulation of signaling pathways plays an essential role in cancer. However, there is not a comprehensive understanding on how…
Abstract Background: Malignant pleural mesothelioma (MPM) is a malignant tumor originating from pleural mesothelial cells and has a high mortality…
Abstract Beta-actin (ACTB), a highly conserved cytoskeleton structural protein, has been regarded as a common housekeep gene and used as…