Aberrant DNA methylation defines isoform usage in cancer, with functional implications
Abstract Alternative transcript isoforms are common in tumors and act as potential drivers of cancer. Mechanisms determining altered isoform expression…
Yun-Ching Chen
Significant associations between driver gene mutations and DNA methylation alterations across many cancer types
Abstract Recent evidence shows that mutations in several driver genes can cause aberrant methylation patterns, a hallmark of cancer. In…