Distinct dosage compensations of ploidy-sensitive and -insensitive X chromosome genes during development and in diseases
Abstract The active X chromosome in mammals is upregulated to balance its dosage to autosomes during evolution. However, it is…
Yuanyan Xiong
Comprehensive Analysis of Large-Scale Transcriptomes from Multiple Cancer Types
Abstract Various abnormalities of transcriptional regulation revealed by RNA sequencing (RNA-seq) have been reported in cancers. However, strategies to integrate…
The landscape of long noncoding RNA-involved and tumor-specific fusions across various cancers
Abstract The majority of the human genome encodes long noncoding RNA (lncRNA) genes, critical regulators of various cellular processes, which…
Pan-cancer analysis identifies telomerase-associated signatures and cancer subtypes
Abstract Background: Cancer cells become immortalized through telomere maintenance mechanisms, such as telomerase reverse transcriptase (TERT) activation. In addition to…