Bioactive Terpenes from Marine Sponges and Their Associated Organisms
Abstract In recent years, marine natural products have continued to serve as a pivotal resource for novel drug discovery. Globally,…
Yuan Yuan
Pan-cancer and single-cell analysis reveal dual roles of lymphocyte activation gene-3 (LAG3) in cancer immunity and prognosis
Abstract Supplementary Information: The online version contains supplementary material available at 10.1038/s41598-024-74808-4. Article type: Research Article Keywords: LAG3, Immune checkpoint,…
Expression characteristics and their functional role of IGFBP gene family in pan-cancer
Abstract Background: Insulin-like growth factor binding proteins (IGFBPs) are critical regulators of the biological activities of insulin-like growth factors. The…
Immunotherapeutic Value of Transcription Factor 19 (TCF19) Associated with Renal Clear Cell Carcinoma: A Comprehensive Analysis of 33 Human Cancer Cases
Abstract Background: We aimed to study the relationship between transcription factor 19 (TCF19) and cancer immunotherapy in the 33 types…
An Integrated Pan-Cancer Analysis of 33 Human Cancers Reveals the Potential Clinical Implications and Immunotherapeutic Value of C-X-C Motif Chemokine Ligand 13
Abstract Background: C-X-C Motif Chemokine Ligand 13 (CXCL13) plays a crucial part in the pathogenesis of numerous lymphoproliferative disorders, inflammatory…
Comprehensive Pan-Cancer Analysis of Heat Shock Protein 110, 90, 70, and 60 Families
Abstract Background: Here we carried out a panoramic analysis of the expression and prognosis of HSP110, HSP90, HSP70, and HSP60…
Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples
Abstract The Cancer Genome Atlas (TCGA) and International Cancer Genome Consortium (ICGC) curated consensus somatic mutation calls using whole exome…
Divergent mutational processes distinguish hypoxic and normoxic tumours
Abstract Many primary tumours have low levels of molecular oxygen (hypoxia), and hypoxic tumours respond poorly to therapy. Pan-cancer molecular…
Comprehensive molecular characterization of mitochondrial genomes in human cancers
Abstract Mitochondria are essential cellular organelles that play critical roles in cancer. Here, as part of the International Cancer Genome…
Systematic characterization of A-to-I RNA editing hotspots in microRNAs across human cancers
Abstract RNA editing, a widespread post-transcriptional mechanism, has emerged as a new player in cancer biology. Recent studies have reported…