CD93 in Health and Disease: Bridging Physiological Functions and Clinical Applications
Abstract CD93 is a highly glycosylated transmembrane glycoprotein with key functional domains, including a C-type lectin-like domain (CTLD) and epidermal…
Xuan Huang
Targeting collagen in tumor extracellular matrix as a novel targeted strategy in cancer immunotherapy
Abstract Collagen, the most abundant protein in mammal, is widely expressed in tissues and organs, as well as tumor extracellular…
A SIRPαFc Fusion Protein Conjugated With the Collagen-Binding Domain for Targeted Immunotherapy of Non-Small Cell Lung Cancer
Abstract The SIRPαFc fusion protein can block the immunosuppressive CD47-SIRPα signal between macrophages and tumor cells as a decoy receptor…
Identification of PAFAH1B3 as Candidate Prognosis Marker and Potential Therapeutic Target for Hepatocellular Carcinoma
Abstract Background: Hepatocellular carcinoma (HCC) is the fourth leading cause of cancer-related deaths worldwide. PAFAH1B3 plays an important role on…
A Combined Effect of Expression Levels of Obesity-Related Genes and Clinical Factors on Cancer Survival Rate
Abstract Obesity is directly associated with the risk of cancer in different organs, including breast, colon, and kidney. However, adipocytes…
Impact of sex, body mass index and initial pathologic diagnosis age on the incidence and prognosis of different types of cancer
Abstract Cancer represents a significant challenge for humankind, as early diagnosis and treatment are difficult to achieve. To systemically investigate…